Vanishing white matter: deregulated integrated stress response as therapy target

OBJECTIVE: Vanishing white matter (VWM) is a fatal, stress‐sensitive leukodystrophy that mainly affects children and is currently without treatment. VWM is caused by recessive mutations in eukaryotic initiation factor 2B (eIF2B) that is crucial for initiation of mRNA translation and its regulation d...

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Detalles Bibliográficos
Autores principales: Abbink, Truus E. M., Wisse, Lisanne E., Jaku, Ermelinda, Thiecke, Michiel J., Voltolini‐González, Daniel, Fritsen, Hein, Bobeldijk, Sander, ter Braak, Timo J., Polder, Emiel, Postma, Nienke L., Bugiani, Marianna, Struijs, Eduard A., Verheijen, Mark, Straat, Nina, van der Sluis, Sophie, Thomas, Adri A. M., Molenaar, Douwe, van der Knaap, Marjo S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689685/
https://www.ncbi.nlm.nih.gov/pubmed/31402619
http://dx.doi.org/10.1002/acn3.50826

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