Identification of novel small molecule inhibitors for solute carrier SGLT1 using proteochemometric modeling

Sodium-dependent glucose co-transporter 1 (SGLT1) is a solute carrier responsible for active glucose absorption. SGLT1 is present in both the renal tubules and small intestine. In contrast, the closely related sodium-dependent glucose co-transporter 2 (SGLT2), a protein that is targeted in the treat...

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Detalles Bibliográficos
Autores principales: Burggraaff, Lindsey, Oranje, Paul, Gouka, Robin, van der Pijl, Pieter, Geldof, Marian, van Vlijmen, Herman W. T., IJzerman, Adriaan P., van Westen, Gerard J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689890/
https://www.ncbi.nlm.nih.gov/pubmed/30767155
http://dx.doi.org/10.1186/s13321-019-0337-8

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