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First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography

The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients (n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using mic...

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Autores principales: Hartmann, Karl, Stein, Klaus-Peter, Neyazi, Belal, Sandalcioglu, Ibrahim Erol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689907/
https://www.ncbi.nlm.nih.gov/pubmed/31447933
http://dx.doi.org/10.1177/1756286419843040
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author Hartmann, Karl
Stein, Klaus-Peter
Neyazi, Belal
Sandalcioglu, Ibrahim Erol
author_facet Hartmann, Karl
Stein, Klaus-Peter
Neyazi, Belal
Sandalcioglu, Ibrahim Erol
author_sort Hartmann, Karl
collection PubMed
description The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients (n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a mean depth of 570 µm frontotemporal. The ABCM showed a mean depth of 74 µm frontotemporal. These results indicate that OCT provides a dynamic, non-invasive tool for real-time imaging of the SAS and adjacent anatomical structures at micrometer spatial resolution. Further studies are necessary to evaluate the value of OCT during microsurgical procedures.
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spelling pubmed-66899072019-08-23 First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography Hartmann, Karl Stein, Klaus-Peter Neyazi, Belal Sandalcioglu, Ibrahim Erol Ther Adv Neurol Disord Advances in Neuroimaging The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients (n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a mean depth of 570 µm frontotemporal. The ABCM showed a mean depth of 74 µm frontotemporal. These results indicate that OCT provides a dynamic, non-invasive tool for real-time imaging of the SAS and adjacent anatomical structures at micrometer spatial resolution. Further studies are necessary to evaluate the value of OCT during microsurgical procedures. SAGE Publications 2019-04-11 /pmc/articles/PMC6689907/ /pubmed/31447933 http://dx.doi.org/10.1177/1756286419843040 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Advances in Neuroimaging
Hartmann, Karl
Stein, Klaus-Peter
Neyazi, Belal
Sandalcioglu, Ibrahim Erol
First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
title First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
title_full First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
title_fullStr First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
title_full_unstemmed First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
title_short First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
title_sort first in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
topic Advances in Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689907/
https://www.ncbi.nlm.nih.gov/pubmed/31447933
http://dx.doi.org/10.1177/1756286419843040
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