SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC

Non-small-cell lung cancer (NSCLC) is the predominant form of lung cancer, and it is regulated by a complex signal transduction network. Single-agent targeted therapy often results in acquired resistance, which leads to treatment failure. In this study, we demonstrated that a combination of the kina...

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Detalles Bibliográficos
Autores principales: Yuan, Man, Xu, Lin-feng, Zhang, Juan, Kong, Si-yuan, Wu, Man, Lao, Yuan-zhi, Zhou, Hua, Zhang, Li, Xu, Hongxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689998/
https://www.ncbi.nlm.nih.gov/pubmed/31428570
http://dx.doi.org/10.3389/fonc.2019.00586

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