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Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration

Repair of degenerated intervertebral discs (IVD) might be established via intradiscal delivery of biologic therapies. Polyester amide polymers (PEA) were evaluated for in vitro cytotoxicity and in vivo biocompatibility, and thereafter intradiscal application of PEA microspheres (PEAMs) in a canine m...

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Detalles Bibliográficos
Autores principales:	Willems, Nicole, Mihov, George, Grinwis, Guy C.M., van Dijk, Maarten, Schumann, Detlef, Bos, Clemens, Strijkers, Gustav J., Dhert, Wouter J.A., Meij, Björn P., Creemers, Laura B., Tryfonidou, Marianna A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690078/ https://www.ncbi.nlm.nih.gov/pubmed/26687460 http://dx.doi.org/10.1002/jbm.b.33579

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