Cargando…

Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain

INTRODUCTION: Magnetic resonance spectroscopy (MRS) enables detailed analysis of the composition of muscular fat tissues such as intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs). The aim of this study was to analyze the EMCL and IMCL of the multifidus muscle (Mm) using MRS in chro...

Descripción completa

Detalles Bibliográficos
Autores principales: Ogon, Izaya, Takebayashi, Tsuneo, Takashima, Hiroyuki, Morita, Tomonori, Yoshimoto, Mitsunori, Terashima, Yoshinori, Yamashita, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Spine Surgery and Related Research 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690088/
https://www.ncbi.nlm.nih.gov/pubmed/31435570
http://dx.doi.org/10.22603/ssrr.2018-0023
_version_ 1783443141853970432
author Ogon, Izaya
Takebayashi, Tsuneo
Takashima, Hiroyuki
Morita, Tomonori
Yoshimoto, Mitsunori
Terashima, Yoshinori
Yamashita, Toshihiko
author_facet Ogon, Izaya
Takebayashi, Tsuneo
Takashima, Hiroyuki
Morita, Tomonori
Yoshimoto, Mitsunori
Terashima, Yoshinori
Yamashita, Toshihiko
author_sort Ogon, Izaya
collection PubMed
description INTRODUCTION: Magnetic resonance spectroscopy (MRS) enables detailed analysis of the composition of muscular fat tissues such as intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs). The aim of this study was to analyze the EMCL and IMCL of the multifidus muscle (Mm) using MRS in chronic low-back pain (CLBP) patients and identify their possible correlations with age, body mass index (BMI), low-back pain (LBP) visual analog scale (VAS) score, cross-sectional area (CSA), and fat infiltration of the Mm. METHODS: Eighty patients (32 men and 48 women; mean age, 64.7 ± 1.3 years; range, 22-83 years) with VAS scores >30 mm for CLBP were included. We analyzed the gender difference and the possible correlations of age, BMI, LBP VAS, CSA, and fat infiltration of the Mm with the IMCL and EMCL of the Mm. The subjects were divided into five groups as per their age range: < 40s, 50s, 60s, 70s, and 80s. We also analyzed the EMCL and IMCL of the Mm as per the fat infiltration classification. RESULTS: CSA was larger in the male group, EMCL was higher in the female group, and there was no significant difference in IMCL between the female and male groups. There was a significant positive correlation of EMCL with age (r = 0.33, p < 0.01) and BMI (r = 0.42, p < 0.01) and a significant negative correlation of EMCL with CSA (r = −0.61, p < 0.01). There was a significant positive correlation between IMCL and VAS (r = 0.43, p < 0.01). The EMCL and CSA of the Mm decreased with age, whereas fat infiltration increased with age. CONCLUSIONS: These results suggest that EMCL could indicate Mm degeneration associated with aging, and IMCL could be an effective objective indicator of CLBP. The EMCL and IMCL of the Mm may be useful prognostic markers in rehabilitation strategies.
format Online
Article
Text
id pubmed-6690088
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Japanese Society for Spine Surgery and Related Research
record_format MEDLINE/PubMed
spelling pubmed-66900882019-08-21 Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain Ogon, Izaya Takebayashi, Tsuneo Takashima, Hiroyuki Morita, Tomonori Yoshimoto, Mitsunori Terashima, Yoshinori Yamashita, Toshihiko Spine Surg Relat Res Original Article INTRODUCTION: Magnetic resonance spectroscopy (MRS) enables detailed analysis of the composition of muscular fat tissues such as intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs). The aim of this study was to analyze the EMCL and IMCL of the multifidus muscle (Mm) using MRS in chronic low-back pain (CLBP) patients and identify their possible correlations with age, body mass index (BMI), low-back pain (LBP) visual analog scale (VAS) score, cross-sectional area (CSA), and fat infiltration of the Mm. METHODS: Eighty patients (32 men and 48 women; mean age, 64.7 ± 1.3 years; range, 22-83 years) with VAS scores >30 mm for CLBP were included. We analyzed the gender difference and the possible correlations of age, BMI, LBP VAS, CSA, and fat infiltration of the Mm with the IMCL and EMCL of the Mm. The subjects were divided into five groups as per their age range: < 40s, 50s, 60s, 70s, and 80s. We also analyzed the EMCL and IMCL of the Mm as per the fat infiltration classification. RESULTS: CSA was larger in the male group, EMCL was higher in the female group, and there was no significant difference in IMCL between the female and male groups. There was a significant positive correlation of EMCL with age (r = 0.33, p < 0.01) and BMI (r = 0.42, p < 0.01) and a significant negative correlation of EMCL with CSA (r = −0.61, p < 0.01). There was a significant positive correlation between IMCL and VAS (r = 0.43, p < 0.01). The EMCL and CSA of the Mm decreased with age, whereas fat infiltration increased with age. CONCLUSIONS: These results suggest that EMCL could indicate Mm degeneration associated with aging, and IMCL could be an effective objective indicator of CLBP. The EMCL and IMCL of the Mm may be useful prognostic markers in rehabilitation strategies. The Japanese Society for Spine Surgery and Related Research 2018-10-10 /pmc/articles/PMC6690088/ /pubmed/31435570 http://dx.doi.org/10.22603/ssrr.2018-0023 Text en Copyright © 2019 by The Japanese Society for Spine Surgery and Related Research https://creativecommons.org/licenses/by-nc-nd/4.0/ Spine Surgery and Related Research is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ogon, Izaya
Takebayashi, Tsuneo
Takashima, Hiroyuki
Morita, Tomonori
Yoshimoto, Mitsunori
Terashima, Yoshinori
Yamashita, Toshihiko
Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain
title Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain
title_full Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain
title_fullStr Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain
title_full_unstemmed Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain
title_short Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain
title_sort quantitative analysis concerning atrophy and fat infiltration of the multifidus muscle with magnetic resonance spectroscopy in chronic low back pain
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690088/
https://www.ncbi.nlm.nih.gov/pubmed/31435570
http://dx.doi.org/10.22603/ssrr.2018-0023
work_keys_str_mv AT ogonizaya quantitativeanalysisconcerningatrophyandfatinfiltrationofthemultifidusmusclewithmagneticresonancespectroscopyinchroniclowbackpain
AT takebayashitsuneo quantitativeanalysisconcerningatrophyandfatinfiltrationofthemultifidusmusclewithmagneticresonancespectroscopyinchroniclowbackpain
AT takashimahiroyuki quantitativeanalysisconcerningatrophyandfatinfiltrationofthemultifidusmusclewithmagneticresonancespectroscopyinchroniclowbackpain
AT moritatomonori quantitativeanalysisconcerningatrophyandfatinfiltrationofthemultifidusmusclewithmagneticresonancespectroscopyinchroniclowbackpain
AT yoshimotomitsunori quantitativeanalysisconcerningatrophyandfatinfiltrationofthemultifidusmusclewithmagneticresonancespectroscopyinchroniclowbackpain
AT terashimayoshinori quantitativeanalysisconcerningatrophyandfatinfiltrationofthemultifidusmusclewithmagneticresonancespectroscopyinchroniclowbackpain
AT yamashitatoshihiko quantitativeanalysisconcerningatrophyandfatinfiltrationofthemultifidusmusclewithmagneticresonancespectroscopyinchroniclowbackpain