Clinical Outcome and Prognostic Factors of Malignant Spinal Dumbbell Tumors

INTRODUCTION: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). METHODS: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. RESULTS: Nineteen of t...

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Detalles Bibliográficos
Autores principales: Matsumoto, Yoshihiro, Kawaguchi, Kenichi, Fukushi, Jun-ichi, Endo, Makoto, Setsu, Nokitaka, Iida, Keiichiro, Baba, Satoshi, Saiwai, Hirokazu, Matsushita, Akinobu, Hayashida, Mitsumasa, Okada, Seiji, Nakashima, Yasuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Spine Surgery and Related Research 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690099/
https://www.ncbi.nlm.nih.gov/pubmed/31435541
http://dx.doi.org/10.22603/ssrr.2018-0004
Descripción
Sumario:INTRODUCTION: To investigate the clinical outcome and prognostic factors of malignant spinal dumbbell tumors (m-SDTs). METHODS: We retrospectively reviewed the clinical outcome of 22 consecutive cases of m-SDTs and analyzed the prognostic factors associated with worse outcome. RESULTS: Nineteen of the 22 cases were managed with surgery (86%), and gross total resection (GTR) was achieved in four cases (21%). The duration of overall survival (OS) ranged from 3 to 140 months, with a median survival time of 15.3 months. The 5 year OS rate was 55.6%. In multivariate analysis, histological subtype (high-grade malignant peripheral nerve sheath tumor) (hazard ratio [HR] 14.9, p = 0.0191), GTR (HR 0.07, p = 0.0343), and presence of local recurrences (HR 11.2, p = 0.0479) were significant and independent predictors of OS. CONCLUSIONS: On the basis of clinical data, we propose that GTR and prevention of local recurrence may improve the clinical outcome of m-SDTs.

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