Role of some epigenetic factors in DNA damage response pathway

The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major l...

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Detalles Bibliográficos
Autores principales: Tiwari, Mrinalini, Parvez, Suhel, Agrawala, Paban K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690236/
https://www.ncbi.nlm.nih.gov/pubmed/31435504
http://dx.doi.org/10.3934/genet.2017.1.69
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author Tiwari, Mrinalini
Parvez, Suhel
Agrawala, Paban K
author_facet Tiwari, Mrinalini
Parvez, Suhel
Agrawala, Paban K
author_sort Tiwari, Mrinalini
collection PubMed
description The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review.
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spelling pubmed-66902362019-08-21 Role of some epigenetic factors in DNA damage response pathway Tiwari, Mrinalini Parvez, Suhel Agrawala, Paban K AIMS Genet Review The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review. AIMS Press 2017-03-24 /pmc/articles/PMC6690236/ /pubmed/31435504 http://dx.doi.org/10.3934/genet.2017.1.69 Text en © 2017 Paban K Agrawala et al., licensee AIMS Press This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
spellingShingle Review
Tiwari, Mrinalini
Parvez, Suhel
Agrawala, Paban K
Role of some epigenetic factors in DNA damage response pathway
title Role of some epigenetic factors in DNA damage response pathway
title_full Role of some epigenetic factors in DNA damage response pathway
title_fullStr Role of some epigenetic factors in DNA damage response pathway
title_full_unstemmed Role of some epigenetic factors in DNA damage response pathway
title_short Role of some epigenetic factors in DNA damage response pathway
title_sort role of some epigenetic factors in dna damage response pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690236/
https://www.ncbi.nlm.nih.gov/pubmed/31435504
http://dx.doi.org/10.3934/genet.2017.1.69
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AT parvezsuhel roleofsomeepigeneticfactorsindnadamageresponsepathway
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