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Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population

BACKGROUND: Vitamin D deficiency or insufficiency has been conducted with increased risk for tuberculosis (TB). Despite this association, discrepancies exist among different studies in different regions. The aim of this study was to evaluate the prevalence of vitamin D deficiency and its predictors...

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Autores principales: Nouri-Vaskeh, Masoud, Sadeghifard, Sepehr, Saleh, Parviz, Farhadi, Jafar, Amraii, Mahan, Ansarin, Khalil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690331/
https://www.ncbi.nlm.nih.gov/pubmed/31423135
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author Nouri-Vaskeh, Masoud
Sadeghifard, Sepehr
Saleh, Parviz
Farhadi, Jafar
Amraii, Mahan
Ansarin, Khalil
author_facet Nouri-Vaskeh, Masoud
Sadeghifard, Sepehr
Saleh, Parviz
Farhadi, Jafar
Amraii, Mahan
Ansarin, Khalil
author_sort Nouri-Vaskeh, Masoud
collection PubMed
description BACKGROUND: Vitamin D deficiency or insufficiency has been conducted with increased risk for tuberculosis (TB). Despite this association, discrepancies exist among different studies in different regions. The aim of this study was to evaluate the prevalence of vitamin D deficiency and its predictors in tuberculosis among the Iranian-Azari population. MATERIALS AND METHODS: A total of 60 participants were enrolled in this study, 30 of which were newly diagnosed TB patients and 30 were healthy volunteers. At least two serum samples were collected, the first sample before the start of anti-TB treatment and the second sample 3 months after the effective treatment. RESULTS: The prevalence of vitamin D deficiency (25 patients vs. 2 healthy individuals; P<0.001) and serum levels of the vitamin D (22.66±15.17 vs. 73.03±25.6 ng/mL; P<0.001) were significantly higher in patients with TB than healthy subjects. Likewise, the prevalence of vitamin D deficiency in the extrapulmonary TB group was higher than that of the pulmonary TB, but this difference was not statistically significant (P=0 .397). Moreover, there was no significant difference between mean levels of vitamin D in patients with tuberculosis before and after treatment (P = 0.787). Linear regression analysis showed there was no significant relationship between vitamin D levels after treatment and age, gender, body site of tuberculosis, and vitamin D levels before treatment, P≥0.68. CONCLUSION: Vitamin D deficiency is higher in patients with tuberculosis than healthy individuals.
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spelling pubmed-66903312019-08-16 Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population Nouri-Vaskeh, Masoud Sadeghifard, Sepehr Saleh, Parviz Farhadi, Jafar Amraii, Mahan Ansarin, Khalil Tanaffos Original Article BACKGROUND: Vitamin D deficiency or insufficiency has been conducted with increased risk for tuberculosis (TB). Despite this association, discrepancies exist among different studies in different regions. The aim of this study was to evaluate the prevalence of vitamin D deficiency and its predictors in tuberculosis among the Iranian-Azari population. MATERIALS AND METHODS: A total of 60 participants were enrolled in this study, 30 of which were newly diagnosed TB patients and 30 were healthy volunteers. At least two serum samples were collected, the first sample before the start of anti-TB treatment and the second sample 3 months after the effective treatment. RESULTS: The prevalence of vitamin D deficiency (25 patients vs. 2 healthy individuals; P<0.001) and serum levels of the vitamin D (22.66±15.17 vs. 73.03±25.6 ng/mL; P<0.001) were significantly higher in patients with TB than healthy subjects. Likewise, the prevalence of vitamin D deficiency in the extrapulmonary TB group was higher than that of the pulmonary TB, but this difference was not statistically significant (P=0 .397). Moreover, there was no significant difference between mean levels of vitamin D in patients with tuberculosis before and after treatment (P = 0.787). Linear regression analysis showed there was no significant relationship between vitamin D levels after treatment and age, gender, body site of tuberculosis, and vitamin D levels before treatment, P≥0.68. CONCLUSION: Vitamin D deficiency is higher in patients with tuberculosis than healthy individuals. National Research Institute of Tuberculosis and Lung Disease 2019-01 /pmc/articles/PMC6690331/ /pubmed/31423135 Text en Copyright© 2019 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nouri-Vaskeh, Masoud
Sadeghifard, Sepehr
Saleh, Parviz
Farhadi, Jafar
Amraii, Mahan
Ansarin, Khalil
Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population
title Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population
title_full Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population
title_fullStr Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population
title_full_unstemmed Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population
title_short Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population
title_sort vitamin d deficiency among patients with tuberculosis: a cross-sectional study in iranian-azari population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690331/
https://www.ncbi.nlm.nih.gov/pubmed/31423135
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