Evaluation of Synthetic Cytochrome P(450)-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu(5) Allosteric Ligands

[Image: see text] Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due to the unexpected nature of these “molecular sw...

Descripción completa

Detalles Bibliográficos
Autores principales: Presley, Christopher C., Perry, Charles K., Childress, Elizabeth S., Mulder, Matthew J., Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690571/
https://www.ncbi.nlm.nih.gov/pubmed/31460402
http://dx.doi.org/10.1021/acsomega.9b02017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690571/
https://www.ncbi.nlm.nih.gov/pubmed/31460402
http://dx.doi.org/10.1021/acsomega.9b02017

Ejemplares similares