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Evaluation of Synthetic Cytochrome P(450)-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu(5) Allosteric Ligands

[Image: see text] Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due to the unexpected nature of these “molecular sw...

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Detalles Bibliográficos
Autores principales:	Presley, Christopher C., Perry, Charles K., Childress, Elizabeth S., Mulder, Matthew J., Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690571/ https://www.ncbi.nlm.nih.gov/pubmed/31460402 http://dx.doi.org/10.1021/acsomega.9b02017

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