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Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region
A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690644/ https://www.ncbi.nlm.nih.gov/pubmed/31411309 http://dx.doi.org/10.1590/0074-02760190079 |
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author | Martins, Rafael Affini Cassu-Corsi, Dandara Nodari, Carolina Silva Cayô, Rodrigo Natsumeda, Larissa Streling, Ana Paula Doi, André Mario da Silva, Roberto José Carvalho Bocalon, Roberta Alessandra Lima Gales, Ana Cristina Pignatari, Antonio Carlos Campos |
author_facet | Martins, Rafael Affini Cassu-Corsi, Dandara Nodari, Carolina Silva Cayô, Rodrigo Natsumeda, Larissa Streling, Ana Paula Doi, André Mario da Silva, Roberto José Carvalho Bocalon, Roberta Alessandra Lima Gales, Ana Cristina Pignatari, Antonio Carlos Campos |
author_sort | Martins, Rafael Affini |
collection | PubMed |
description | A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C(2611)T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes). |
format | Online Article Text |
id | pubmed-6690644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-66906442019-08-23 Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region Martins, Rafael Affini Cassu-Corsi, Dandara Nodari, Carolina Silva Cayô, Rodrigo Natsumeda, Larissa Streling, Ana Paula Doi, André Mario da Silva, Roberto José Carvalho Bocalon, Roberta Alessandra Lima Gales, Ana Cristina Pignatari, Antonio Carlos Campos Mem Inst Oswaldo Cruz Short Communication A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C(2611)T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes). Instituto Oswaldo Cruz, Ministério da Saúde 2019-08-12 /pmc/articles/PMC6690644/ /pubmed/31411309 http://dx.doi.org/10.1590/0074-02760190079 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Short Communication Martins, Rafael Affini Cassu-Corsi, Dandara Nodari, Carolina Silva Cayô, Rodrigo Natsumeda, Larissa Streling, Ana Paula Doi, André Mario da Silva, Roberto José Carvalho Bocalon, Roberta Alessandra Lima Gales, Ana Cristina Pignatari, Antonio Carlos Campos Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region |
title | Temporal evolution of antimicrobial resistance among
Neisseria gonorrhoeae clinical isolates in the most
populated South American Metropolitan Region |
title_full | Temporal evolution of antimicrobial resistance among
Neisseria gonorrhoeae clinical isolates in the most
populated South American Metropolitan Region |
title_fullStr | Temporal evolution of antimicrobial resistance among
Neisseria gonorrhoeae clinical isolates in the most
populated South American Metropolitan Region |
title_full_unstemmed | Temporal evolution of antimicrobial resistance among
Neisseria gonorrhoeae clinical isolates in the most
populated South American Metropolitan Region |
title_short | Temporal evolution of antimicrobial resistance among
Neisseria gonorrhoeae clinical isolates in the most
populated South American Metropolitan Region |
title_sort | temporal evolution of antimicrobial resistance among
neisseria gonorrhoeae clinical isolates in the most
populated south american metropolitan region |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690644/ https://www.ncbi.nlm.nih.gov/pubmed/31411309 http://dx.doi.org/10.1590/0074-02760190079 |
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