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Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK

Autophagy, a membrane-dependent catabolic process, ensures survival of aging cells and depends on the cellular energetic status. Acetyl-CoA carboxylase 1 (Acc1) connects central energy metabolism to lipid biosynthesis and is rate-limiting for the de novo synthesis of lipids. However, it is unclear h...

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Detalles Bibliográficos
Autores principales:	Gross, Angelina S., Zimmermann, Andreas, Pendl, Tobias, Schroeder, Sabrina, Schoenlechner, Hannes, Knittelfelder, Oskar, Lamplmayr, Laura, Santiso, Ana, Aufschnaiter, Andreas, Waltenstorfer, Daniel, Ortonobes Lara, Sandra, Stryeck, Sarah, Kast, Christina, Ruckenstuhl, Christoph, Hofer, Sebastian J., Michelitsch, Birgit, Woelflingseder, Martina, Müller, Rolf, Carmona-Gutierrez, Didac, Madl, Tobias, Büttner, Sabrina, Fröhlich, Kai-Uwe, Shevchenko, Andrej, Eisenberg, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690696/ https://www.ncbi.nlm.nih.gov/pubmed/31209110 http://dx.doi.org/10.1074/jbc.RA118.007020

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