Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis

Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Reas S., Baumann, Bailey, Dine, Kimberly, Song, Ying, Dunaief, Joshua L., Kim, Sangwon F., Shindler, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690882/
https://www.ncbi.nlm.nih.gov/pubmed/31406150
http://dx.doi.org/10.1038/s41598-019-48087-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690882/
https://www.ncbi.nlm.nih.gov/pubmed/31406150
http://dx.doi.org/10.1038/s41598-019-48087-3

Ejemplares similares