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Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis
Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690882/ https://www.ncbi.nlm.nih.gov/pubmed/31406150 http://dx.doi.org/10.1038/s41598-019-48087-3 |