MLP-deficient human pluripotent stem cell derived cardiomyocytes develop hypertrophic cardiomyopathy and heart failure phenotypes due to abnormal calcium handling

Muscle LIM protein (MLP, CSRP3) is a key regulator of striated muscle function, and its mutations can lead to both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in patients. However, due to lack of human models, mechanisms underlining the pathogenesis of MLP defects remain uncle...

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Detalles Bibliográficos
Autores principales: Li, Xiaowei, Lu, Wen-Jing, Li, Ya’nan, Wu, Fujian, Bai, Rui, Ma, Shuhong, Dong, Tao, Zhang, Hongjia, Lee, Andrew S., Wang, Yongming, Lan, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690906/
https://www.ncbi.nlm.nih.gov/pubmed/31406109
http://dx.doi.org/10.1038/s41419-019-1826-4

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