Cargando…

Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin against HepG2 cells via apoptosis induction

Curcumin (Cur) has been reported to have anti-hepatocellular carcinoma activity but its poor oral bioavailability limits its further development as a chemotherapeutic agent. We synthesized previously a succinate ester prodrug of Cur, curcumin diethyl disuccinate (CurDD) with better chemical stabilit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muangnoi, Chawanphat, Ratnatilaka Na Bhuket, Pahweenvaj, Jithavech, Ponsiree, Supasena, Wiwat, Paraoan, Luminita, Patumraj, Suthiluk, Rojsitthisak, Pornchai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690956/ https://www.ncbi.nlm.nih.gov/pubmed/31406217 http://dx.doi.org/10.1038/s41598-019-48124-1

Ejemplares similares

Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice
por: Muangnoi, Chawanphat, et al.
Publicado: (2019)

Interspecies differences in stability kinetics and plasma esterases involved in hydrolytic activation of curcumin diethyl disuccinate, a prodrug of curcumin
por: Ratnatilaka Na Bhuket, Pahweenvaj, et al.
Publicado: (2019)

In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species
por: Jithavech, Ponsiree, et al.
Publicado: (2020)

Protective Effects of Curcumin Ester Prodrug, Curcumin Diethyl Disuccinate against H(2)O(2)-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells: Potential Therapeutic Avenues for Age-Related Macular Degeneration
por: Muangnoi, Chawanphat, et al.
Publicado: (2019)

A stability-indicating UPLC method for the determination of curcumin diethyl disuccinate, an ester prodrug of curcumin, in raw materials
por: Ratnatilaka Na Bhuket, Pahweenvaj, et al.
Publicado: (2020)

Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity
por: Jithavech, Ponsiree, et al.
Publicado: (2022)

A Novel Curcumin-Mycophenolic Acid Conjugate Inhibited Hyperproliferation of Tumor Necrosis Factor-Alpha-Induced Human Keratinocyte Cells
por: Yuyun, Yonelian, et al.
Publicado: (2021)

Self-Assembled Thermoresponsive Nanogel from Grafted Hyaluronic Acid as a Biocompatible Delivery Platform for Curcumin with Enhanced Drug Loading and Biological Activities
por: Luckanagul, Jittima Amie, et al.
Publicado: (2021)

Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid
por: Sorasitthiyanukarn, Feuangthit Niyamissara, et al.
Publicado: (2020)

Molecular Insight into the Anti-Inflammatory Effects of the Curcumin Ester Prodrug Curcumin Diglutaric Acid In Vitro and In Vivo
por: Phumsuay, Rianthong, et al.
Publicado: (2020)

Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice
por: Limcharoen, Thanchanok, et al.
Publicado: (2020)

Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain
por: Dasuni Wasana, Peththa Wadu, et al.
Publicado: (2022)

A Stability-Indicating Ultra Performance Liquid Chromato-Graphic (UPLC) Method for the Determination of a Mycophenolic Acid-Curcumin Conjugate and Its Applications to Chemical Kinetic Studies
por: Yuyun, Yonelian, et al.
Publicado: (2021)

Synergistic Effects of Photo-Irradiation and Curcumin-Chitosan/Alginate Nanoparticles on Tumor Necrosis Factor-Alpha-Induced Psoriasis-Like Proliferation of Keratinocytes
por: Gomez, Clinton, et al.
Publicado: (2019)

Protective Effects of a Lutein Ester Prodrug, Lutein Diglutaric Acid, against H(2)O(2)-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells
por: Muangnoi, Chawanphat, et al.
Publicado: (2021)

Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice
por: Yoysungnoen-Chintana, Pornphrom, et al.
Publicado: (2014)

Molecular Mechanisms of Curcumin on Diabetes-Induced Endothelial Dysfunctions: Txnip, ICAM-1, and NOX2 Expressions
por: Wongeakin, Natchaya, et al.
Publicado: (2014)

Fabrication of Curcumin Diethyl γ-Aminobutyrate-Loaded Chitosan-Coated Magnetic Nanocarriers for Improvement of Cytotoxicity against Breast Cancer Cells
por: Hansapaiboon, Supakarn, et al.
Publicado: (2022)

Curcumin Attenuates Gastric Cancer Induced by N-Methyl-N-Nitrosourea and Saturated Sodium Chloride in Rats
por: Sintara, Kawiya, et al.
Publicado: (2012)

Curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and NF-κB suppression
por: Rungseesantivanon, Sirada, et al.
Publicado: (2010)

Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition
por: Rungseesantivanon, Sirada, et al.
Publicado: (2010)

Mechanistic Insight into the Effects of Curcumin on Neuroinflammation-Driven Chronic Pain
por: Hasriadi,, et al.
Publicado: (2021)

Anti-Inflammatory Activity of Oxyresveratrol Tetraacetate, an Ester Prodrug of Oxyresveratrol, on Lipopolysaccharide-Stimulated RAW264.7 Macrophage Cells
por: Thaweesest, Wuttinont, et al.
Publicado: (2022)

Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-κB, ICAM-1, MMP-9 and caspase-3 expression
por: Li, Wei, et al.
Publicado: (2017)

Potential Oral Anticancer Therapeutic Agents of Hexahydrocurcumin-Encapsulated Chitosan Nanoparticles against MDA-MB-231 Breast Cancer Cells
por: Sorasitthiyanukarn, Feuangthit N., et al.
Publicado: (2023)

Curcumin Effect on Copper Transport in HepG2 Cells
por: Berzina, Anita, et al.
Publicado: (2018)

Co-administration of Pregabalin and Curcumin Synergistically Decreases Pain-Like Behaviors in Acute Nociceptive Pain Murine Models
por: Leksiri, Sarinee, et al.
Publicado: (2020)

Hydroxyethyl Starch Curcumin Enhances Antiproliferative Effect of Curcumin Against HepG2 Cells via Apoptosis and Autophagy Induction
por: Jiang, Linhai, et al.
Publicado: (2021)

Eriodictyol Attenuates H(2)O(2)-Induced Oxidative Damage in Human Dermal Fibroblasts through Enhanced Capacity of Antioxidant Machinery
por: Buranasudja, Visarut, et al.
Publicado: (2022)

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects
por: Boonrueng, Pawana, et al.
Publicado: (2022)

Antioxidant Activities and Protective Effects of Dendropachol, a New Bisbibenzyl Compound from Dendrobium pachyglossum, on Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Keratinocytes
por: Warinhomhoun, Sakan, et al.
Publicado: (2021)

Curcumin in neurology
por: Gude, Dilip
Publicado: (2012)

Curcumin and Health
por: Pulido-Moran, Mario, et al.
Publicado: (2016)

Curcumin and Endometriosis
por: Vallée, Alexandre, et al.
Publicado: (2020)

Curcumin and Cancer
por: Giordano, Antonio, et al.
Publicado: (2019)

Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin
por: Wang, Ting-ye, et al.
Publicado: (2019)

Curcumin-primed and curcumin-loaded exosomes: potential neural therapy
por: Kalani, Anuradha, et al.
Publicado: (2017)

Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition
por: Moniruzzaman, Mohammad, et al.
Publicado: (2020)

Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives
por: Antonelli, Anthony C., et al.
Publicado: (2014)

Inhibition of HIV-1 by curcumin A, a novel curcumin analog
por: Kumari, Namita, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mjidh5hnu3f0ia9ke6jd9541u7