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A thermosensitive electromechanical model for detecting biological particles
Miniature electromechanical systems form a class of bioMEMS that can provide appropriate sensitivity. In this research, a thermo-electro-mechanical model is presented to detect biological particles in the microscale. Identification in the model is based on analyzing pull-in instability parameters an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691007/ https://www.ncbi.nlm.nih.gov/pubmed/31406216 http://dx.doi.org/10.1038/s41598-019-48177-2 |
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author | SoltanRezaee, Masoud Bodaghi, Mahdi Farrokhabadi, Amin |
author_facet | SoltanRezaee, Masoud Bodaghi, Mahdi Farrokhabadi, Amin |
author_sort | SoltanRezaee, Masoud |
collection | PubMed |
description | Miniature electromechanical systems form a class of bioMEMS that can provide appropriate sensitivity. In this research, a thermo-electro-mechanical model is presented to detect biological particles in the microscale. Identification in the model is based on analyzing pull-in instability parameters and frequency shifts. Here, governing equations are derived via the extended Hamilton’s principle. The coupled effects of system parameters such as surface layer energy, electric field correction, and material properties are incorporated in this thermosensitive model. Afterward, the accuracy of the present model and obtained results are validated with experimental, analytical, and numerical data for several cases. Performing a parametric study reveals that mechanical properties of biosensors can significantly affect the detection sensitivity of actuated ultra-small detectors and should be taken into account. Furthermore, it is shown that the number or dimension of deposited particles on the sensing zone can be estimated by investigating the changes in the threshold voltage, electrode deflection, and frequency shifts. The present analysis is likely to provide pertinent guidelines to design thermal switches and miniature detectors with the desired performance. The developed biosensor is more appropriate to detect and characterize viruses in samples with different temperatures. |
format | Online Article Text |
id | pubmed-6691007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66910072019-08-15 A thermosensitive electromechanical model for detecting biological particles SoltanRezaee, Masoud Bodaghi, Mahdi Farrokhabadi, Amin Sci Rep Article Miniature electromechanical systems form a class of bioMEMS that can provide appropriate sensitivity. In this research, a thermo-electro-mechanical model is presented to detect biological particles in the microscale. Identification in the model is based on analyzing pull-in instability parameters and frequency shifts. Here, governing equations are derived via the extended Hamilton’s principle. The coupled effects of system parameters such as surface layer energy, electric field correction, and material properties are incorporated in this thermosensitive model. Afterward, the accuracy of the present model and obtained results are validated with experimental, analytical, and numerical data for several cases. Performing a parametric study reveals that mechanical properties of biosensors can significantly affect the detection sensitivity of actuated ultra-small detectors and should be taken into account. Furthermore, it is shown that the number or dimension of deposited particles on the sensing zone can be estimated by investigating the changes in the threshold voltage, electrode deflection, and frequency shifts. The present analysis is likely to provide pertinent guidelines to design thermal switches and miniature detectors with the desired performance. The developed biosensor is more appropriate to detect and characterize viruses in samples with different temperatures. Nature Publishing Group UK 2019-08-12 /pmc/articles/PMC6691007/ /pubmed/31406216 http://dx.doi.org/10.1038/s41598-019-48177-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article SoltanRezaee, Masoud Bodaghi, Mahdi Farrokhabadi, Amin A thermosensitive electromechanical model for detecting biological particles |
title | A thermosensitive electromechanical model for detecting biological particles |
title_full | A thermosensitive electromechanical model for detecting biological particles |
title_fullStr | A thermosensitive electromechanical model for detecting biological particles |
title_full_unstemmed | A thermosensitive electromechanical model for detecting biological particles |
title_short | A thermosensitive electromechanical model for detecting biological particles |
title_sort | thermosensitive electromechanical model for detecting biological particles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691007/ https://www.ncbi.nlm.nih.gov/pubmed/31406216 http://dx.doi.org/10.1038/s41598-019-48177-2 |
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