SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines

SMARCA4/BRG1 and SMARCA2/BRM, the two mutually exclusive catalytic subunits of the BAF complex, display a well-established synthetic lethal relationship in SMARCA4-deficient cancers. Using CRISPR-Cas9 screening, we identify SMARCA4 as a novel dependency in SMARCA2-deficient esophageal squamous cell...

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Detalles Bibliográficos
Autores principales: Ehrenhöfer-Wölfer, Katharina, Puchner, Teresa, Schwarz, Cornelia, Rippka, Janine, Blaha-Ostermann, Silvia, Strobl, Ursula, Hörmann, Alexandra, Bader, Gerd, Kornigg, Stefan, Zahn, Stephan, Sommergruber, Wolfgang, Schweifer, Norbert, Zichner, Thomas, Schlattl, Andreas, Neumüller, Ralph A., Shi, Junwei, Vakoc, Christopher R., Kögl, Manfred, Petronczki, Mark, Kraut, Norbert, Pearson, Mark A., Wöhrle, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691015/
https://www.ncbi.nlm.nih.gov/pubmed/31406271
http://dx.doi.org/10.1038/s41598-019-48152-x

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