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Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response

Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform α-syn-98 is generated by excision of exon-3 and exon-5 of the α-syn...

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Detalles Bibliográficos
Autores principales:	Du, Tingfu, Wu, Zhengcun, Luo, Haiyu, Lu, Shuaiyao, Ma, Kaili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691047/ https://www.ncbi.nlm.nih.gov/pubmed/31447645 http://dx.doi.org/10.3389/fnmol.2019.00189

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