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Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection

In recent decades, cancer and multidrug resistance have become a worldwide problem, resulting in high morbidity and mortality. Some infectious agents like Streptococcus pneumoniae, Stomatococcus mucilaginous, Staphylococcus spp., E. coli. Klebsiella spp., Pseudomonas aeruginosa, Candida spp., Helico...

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Autores principales: Rodrigues, Gisele, Silva, Gislaine Greice Oliveira, Buccini, Danieli Fernanda, Duque, Harry Morales, Dias, Simoni Campos, Franco, Octávio Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691048/
https://www.ncbi.nlm.nih.gov/pubmed/31447795
http://dx.doi.org/10.3389/fmicb.2019.01690
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author Rodrigues, Gisele
Silva, Gislaine Greice Oliveira
Buccini, Danieli Fernanda
Duque, Harry Morales
Dias, Simoni Campos
Franco, Octávio Luiz
author_facet Rodrigues, Gisele
Silva, Gislaine Greice Oliveira
Buccini, Danieli Fernanda
Duque, Harry Morales
Dias, Simoni Campos
Franco, Octávio Luiz
author_sort Rodrigues, Gisele
collection PubMed
description In recent decades, cancer and multidrug resistance have become a worldwide problem, resulting in high morbidity and mortality. Some infectious agents like Streptococcus pneumoniae, Stomatococcus mucilaginous, Staphylococcus spp., E. coli. Klebsiella spp., Pseudomonas aeruginosa, Candida spp., Helicobacter pylori, hepatitis B and C, and human papillomaviruses (HPV) have been associated with the development of cancer. Chemotherapy, radiotherapy and antibiotics are the conventional treatment for cancer and infectious disease. This treatment causes damage in healthy cells and tissues, and usually triggers systemic side-effects, as well as drug resistance. Therefore, the search for new treatments is urgent, in order to improve efficacy and also reduce side-effects. Proteins and peptides originating from bacteria can thus be a promising alternative to conventional treatments used nowadays against cancer and infectious disease. These molecules have demonstrated specific activity against cancer cells and bacterial infection; indeed, proteins and peptides can be considered as future antimicrobial and anticancer drugs. In this context, this review will focus on the desirable characteristics of proteins and peptides from bacterial sources that demonstrated activity against microbial infections and cancer, as well as their efficacy in vitro and in vivo.
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spelling pubmed-66910482019-08-23 Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection Rodrigues, Gisele Silva, Gislaine Greice Oliveira Buccini, Danieli Fernanda Duque, Harry Morales Dias, Simoni Campos Franco, Octávio Luiz Front Microbiol Microbiology In recent decades, cancer and multidrug resistance have become a worldwide problem, resulting in high morbidity and mortality. Some infectious agents like Streptococcus pneumoniae, Stomatococcus mucilaginous, Staphylococcus spp., E. coli. Klebsiella spp., Pseudomonas aeruginosa, Candida spp., Helicobacter pylori, hepatitis B and C, and human papillomaviruses (HPV) have been associated with the development of cancer. Chemotherapy, radiotherapy and antibiotics are the conventional treatment for cancer and infectious disease. This treatment causes damage in healthy cells and tissues, and usually triggers systemic side-effects, as well as drug resistance. Therefore, the search for new treatments is urgent, in order to improve efficacy and also reduce side-effects. Proteins and peptides originating from bacteria can thus be a promising alternative to conventional treatments used nowadays against cancer and infectious disease. These molecules have demonstrated specific activity against cancer cells and bacterial infection; indeed, proteins and peptides can be considered as future antimicrobial and anticancer drugs. In this context, this review will focus on the desirable characteristics of proteins and peptides from bacterial sources that demonstrated activity against microbial infections and cancer, as well as their efficacy in vitro and in vivo. Frontiers Media S.A. 2019-08-06 /pmc/articles/PMC6691048/ /pubmed/31447795 http://dx.doi.org/10.3389/fmicb.2019.01690 Text en Copyright © 2019 Rodrigues, Silva, Buccini, Duque, Dias and Franco. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Rodrigues, Gisele
Silva, Gislaine Greice Oliveira
Buccini, Danieli Fernanda
Duque, Harry Morales
Dias, Simoni Campos
Franco, Octávio Luiz
Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection
title Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection
title_full Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection
title_fullStr Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection
title_full_unstemmed Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection
title_short Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection
title_sort bacterial proteinaceous compounds with multiple activities toward cancers and microbial infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691048/
https://www.ncbi.nlm.nih.gov/pubmed/31447795
http://dx.doi.org/10.3389/fmicb.2019.01690
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