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Synthesis of Tris-Heterocycles via a Cascade IMCR/Aza Diels-Alder + CuAAC Strategy

6-Triazolylmethyl-pyrrolo[3,4-b]pyridin-5-one tris-heterocycles were synthesized in 43–57% overall yields. The two-stage synthesis involved a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) followed by a copper-assisted alkyne-azide [3+2] cycloaddition (CuAAC). This efficient and...

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Detalles Bibliográficos
Autores principales:	Rentería-Gómez, Manuel A., Islas-Jácome, Alejandro, Pharande, Shrikant G., Vosburg, David A., Gámez-Montaño, Rocío
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691067/ https://www.ncbi.nlm.nih.gov/pubmed/31448260 http://dx.doi.org/10.3389/fchem.2019.00546

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