Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location

Background: Bifurcation and sidewall aneurysms have different rupture risks, but whether this difference comes from the location of the aneurysm is not clear. The objective of this study is to illustrate the rationality of ranking bifurcation configuration as an independent risk factor for aneurysm...

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Autores principales: Liu, Qinglin, Jiang, Peng, Jiang, Yuhua, Li, Shaolin, Ge, Huijian, Jin, Hengwei, Li, Youxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691088/
https://www.ncbi.nlm.nih.gov/pubmed/31447764
http://dx.doi.org/10.3389/fneur.2019.00844
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author Liu, Qinglin
Jiang, Peng
Jiang, Yuhua
Li, Shaolin
Ge, Huijian
Jin, Hengwei
Li, Youxiang
author_facet Liu, Qinglin
Jiang, Peng
Jiang, Yuhua
Li, Shaolin
Ge, Huijian
Jin, Hengwei
Li, Youxiang
author_sort Liu, Qinglin
collection PubMed
description Background: Bifurcation and sidewall aneurysms have different rupture risks, but whether this difference comes from the location of the aneurysm is not clear. The objective of this study is to illustrate the rationality of ranking bifurcation configuration as an independent risk factor for aneurysm rupture. Methods: Morphological features of 719 aneurysms (216 ruptured) were automatically extracted from a consecutive cohort of patients via PyRadiomics. Rupture risks and morphological features were compared between bifurcation and sidewall aneurysms, and lasso regression was applied to explore the morphological determinants for rupture in bifurcation and sidewall aneurysms. Rupture risks and morphological features of bifurcation aneurysms in different locations were analyzed. Multivariate regression was performed to explore the risk factors for aneurysm rupture. Results: Twelve morphological features were automatically extracted from PyRadiomics implemented in Python. The rupture risks were higher in bifurcation aneurysms (P < 0.01), and morphological features Elongation and Flatness were much lower in ruptured bifurcation than sidewall aneurysms (P = 0.036, 0.011, respectively). Elongation and Flatness were the morphological determinants for rupture in bifurcation aneurysms, whereas Elongation and SphericalDisproportion were determinants for sidewall aneurysms. Different rupture risks and morphological features were found between sidewall and bifurcation aneurysms of the same location, and among bifurcation aneurysms of different locations. In multivariate regression, bifurcation configuration was an independent risk factor for aneurysm rupture (OR 3.007, 95% CI 1.752–5.248, P < 0.001). Conclusions: Sidewall and bifurcation aneurysms and bifurcation aneurysms of different locations have different rupture risks and morphological features. Bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location.
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spelling pubmed-66910882019-08-23 Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location Liu, Qinglin Jiang, Peng Jiang, Yuhua Li, Shaolin Ge, Huijian Jin, Hengwei Li, Youxiang Front Neurol Neurology Background: Bifurcation and sidewall aneurysms have different rupture risks, but whether this difference comes from the location of the aneurysm is not clear. The objective of this study is to illustrate the rationality of ranking bifurcation configuration as an independent risk factor for aneurysm rupture. Methods: Morphological features of 719 aneurysms (216 ruptured) were automatically extracted from a consecutive cohort of patients via PyRadiomics. Rupture risks and morphological features were compared between bifurcation and sidewall aneurysms, and lasso regression was applied to explore the morphological determinants for rupture in bifurcation and sidewall aneurysms. Rupture risks and morphological features of bifurcation aneurysms in different locations were analyzed. Multivariate regression was performed to explore the risk factors for aneurysm rupture. Results: Twelve morphological features were automatically extracted from PyRadiomics implemented in Python. The rupture risks were higher in bifurcation aneurysms (P < 0.01), and morphological features Elongation and Flatness were much lower in ruptured bifurcation than sidewall aneurysms (P = 0.036, 0.011, respectively). Elongation and Flatness were the morphological determinants for rupture in bifurcation aneurysms, whereas Elongation and SphericalDisproportion were determinants for sidewall aneurysms. Different rupture risks and morphological features were found between sidewall and bifurcation aneurysms of the same location, and among bifurcation aneurysms of different locations. In multivariate regression, bifurcation configuration was an independent risk factor for aneurysm rupture (OR 3.007, 95% CI 1.752–5.248, P < 0.001). Conclusions: Sidewall and bifurcation aneurysms and bifurcation aneurysms of different locations have different rupture risks and morphological features. Bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location. Frontiers Media S.A. 2019-08-06 /pmc/articles/PMC6691088/ /pubmed/31447764 http://dx.doi.org/10.3389/fneur.2019.00844 Text en Copyright © 2019 Liu, Jiang, Jiang, Li, Ge, Jin and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Liu, Qinglin
Jiang, Peng
Jiang, Yuhua
Li, Shaolin
Ge, Huijian
Jin, Hengwei
Li, Youxiang
Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location
title Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location
title_full Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location
title_fullStr Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location
title_full_unstemmed Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location
title_short Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location
title_sort bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691088/
https://www.ncbi.nlm.nih.gov/pubmed/31447764
http://dx.doi.org/10.3389/fneur.2019.00844
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