Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and survival. This is controlled by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), the pro...

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Detalles Bibliográficos
Autores principales: Burmistrova, Olga, Olias-Arjona, Ana, Lapresa, Rebeca, Jimenez-Blasco, Daniel, Eremeeva, Tatiana, Shishov, Dmitry, Romanov, Sergei, Zakurdaeva, Kristina, Almeida, Angeles, Fedichev, Peter O., Bolaños, Juan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691133/
https://www.ncbi.nlm.nih.gov/pubmed/31406177
http://dx.doi.org/10.1038/s41598-019-48196-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691133/
https://www.ncbi.nlm.nih.gov/pubmed/31406177
http://dx.doi.org/10.1038/s41598-019-48196-z

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