High glucose and bupivacaine-induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK-ATF4-CHOP and IRE1-TRAF2 signaling pathways

Bupivacaine has previously been reported to induce neurotoxicity, which is further enhanced by high glucose levels. In the present study, the underlying molecular mechanisms via which bupivacaine induces cytotoxicity under high glucose conditions were investigated in cultured human SH-SY5Y cells. In...

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Detalles Bibliográficos
Autores principales: Liu, Yongzhe, Sun, Li, Ma, Yaqun, Wei, Biyu, Gao, Minglong, Shang, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691238/
https://www.ncbi.nlm.nih.gov/pubmed/31524237
http://dx.doi.org/10.3892/mmr.2019.10524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691238/
https://www.ncbi.nlm.nih.gov/pubmed/31524237
http://dx.doi.org/10.3892/mmr.2019.10524

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