Cargando…

Two novel 1,4-naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species-mediated MAPK/Akt/STAT3 signaling pathways

1,4-Naphthoquinone derivatives have superior anticancer effects, but their use has been severely limited in clinical practice due to adverse side effects. To reduce the side effects and extend the anticancer effects of 1,4-naphthoquinone derivatives, 2-(butane-1-sulfinyl)-1,4-naphthoquinone (BQ) and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hao, Luo, Ying-Hua, Shen, Gui-Nan, Piao, Xian-Ji, Xu, Wan-Ting, Zhang, Yi, Wang, Jia-Ru, Feng, Yu-Chao, Li, Jin-Qian, Zhang, Yu, Zhang, Tong, Wang, Shi-Nong, Xue, Hui, Wang, Hong-Xing, Wang, Chang-Yuan, Jin, Cheng-Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691246/ https://www.ncbi.nlm.nih.gov/pubmed/31322207 http://dx.doi.org/10.3892/mmr.2019.10500

Ejemplares similares

Novel 1,4-naphthoquinone derivatives induce reactive oxygen species-mediated apoptosis in liver cancer cells
por: Wang, Yue, et al.
Publicado: (2019)

2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells
por: Shen, Gui-Nan, et al.
Publicado: (2020)

2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways
por: Sun, Hu-Nan, et al.
Publicado: (2016)

Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells
por: Meng, Ling-Qi, et al.
Publicado: (2018)

Novel 2-Amino-1,4-Naphthoquinone Derivatives Induce A549 Cell Death through Autophagy
por: Tan, Hua-Yuan, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Lipophilic 1,4-Naphthoquinone Derivatives against Human Cancer Cell Lines
por: Wang, Shao-Hung, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Novel 2-Amino-1,4-Naphthoquinone Amide-Oxime Derivatives as Potent IDO1/STAT3 Dual Inhibitors with Prospective Antitumor Effects
por: Huang, Ri-Zhen, et al.
Publicado: (2023)

Synthetic Tryptanthrin Derivatives Induce Cell Cycle Arrest and Apoptosis via Akt and MAPKs in Human Hepatocellular Carcinoma Cells
por: Gao, Jing-Yan, et al.
Publicado: (2021)

Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway
por: Liu, Yadong, et al.
Publicado: (2021)

Naphthoquinones from Onosma paniculata Induce Cell-Cycle Arrest and Apoptosis in Melanoma Cells
por: Kretschmer, Nadine, et al.
Publicado: (2012)

Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone
por: Yu, Jin-Sheng, et al.
Publicado: (2012)

Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway
por: Zhou, Chengfang, et al.
Publicado: (2016)

DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate
por: Ourique, Fabiana, et al.
Publicado: (2015)

Inhibiting MAPK14 showed anti-prolactinoma effect
por: Ding, Qiao-yan, et al.
Publicado: (2020)

Calycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-κB Pathway
por: Zhang, Yu, et al.
Publicado: (2021)

Quinalizarin induces ROS-mediated apoptosis via the MAPK, STAT3 and NF-κB signaling pathways in human breast cancer cells
por: Zang, Yan-Qing, et al.
Publicado: (2019)

1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation
por: Ravichandiran, Palanisamy, et al.
Publicado: (2019)

5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1/2/AKT/STAT3 signaling pathways in glioblastoma cells
por: Zhang, Xuehua, et al.
Publicado: (2023)

Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Human Gastric Cancer Cells
por: Sheng, Ya-Nan, et al.
Publicado: (2020)

Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells
por: Zhao, Lan-Juan, et al.
Publicado: (2011)

t-BuOK mediated oxidative coupling amination of 1,4-naphthoquinone and related 3-indolylnaphthoquinones with amines
por: Dong, Yu, et al.
Publicado: (2021)

Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2021)

Synthesis and Antimicrobial Evaluation of 1,4‐Naphthoquinone Derivatives as Potential Antibacterial Agents
por: Ravichandiran, Palanisamy, et al.
Publicado: (2019)

5-Hydroxy-8-nitro-1,4-naphthoquinone
por: Tan, Daniel Teoh-Chuan, et al.
Publicado: (2008)

B(C(6)F(5))(3)-Catalyzed C–C Coupling of 1,4-Naphthoquinones with the C-3 Position of Indole Derivatives in Water
por: Dong, Yu, et al.
Publicado: (2019)

2-Methoxy-1,4-naphthoquinone (MNQ) regulates cancer key genes of MAPK, PI3K, and NF-κB pathways in Raji cells
por: Wong, Teck Yew, et al.
Publicado: (2022)

A Survey on the Reactivity of Phenyliodonium Ylide of 2-Hydroxy-1,4-Naphthoquinone with Amino Compounds
por: Spagou, Konstantina, et al.
Publicado: (2005)

Baker’s Yeast-Based Microbial Fuel Cell Mediated by 2-Methyl-1,4-Naphthoquinone
por: Rozene, Juste, et al.
Publicado: (2021)

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas
por: Wang, Shuman, et al.
Publicado: (2021)

Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone
por: Blauenburg, Bastian, et al.
Publicado: (2012)

2-Chloro-3-(4-chlorobenzamido)-1,4-naphthoquinone
por: Brandy, Yakini, et al.
Publicado: (2008)

Aromatase inhibitory activity of 1,4-naphthoquinone derivatives and QSAR study
por: Prachayasittikul, Veda, et al.
Publicado: (2017)

Removal of 1,4-Naphthoquinone by Birnessite-Catalyzed Oxidation: Effect of Phenolic Mediators and the Reaction Pathway
por: Lee, Han-Saem, et al.
Publicado: (2020)

A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells
por: KARAKAŞ, Didem, et al.
Publicado: (2019)

Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells
por: Ke, Fayong, et al.
Publicado: (2017)

Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells
por: Luo, Ming, et al.
Publicado: (2016)

Myricetin Protects Cells against Oxidative Stress-Induced Apoptosis via Regulation of PI3K/Akt and MAPK Signaling Pathways
por: Kang, Kyoung Ah, et al.
Publicado: (2010)

The Effects of 1,4-Naphthoquinone (NQ) and Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone, DHNQ) Individually and in Combination on Growth and Oxidative Stress in Maize (Zea mays L.) Seedlings
por: Karcz, Waldemar, et al.
Publicado: (2023)

Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways
por: Yang, Wei, et al.
Publicado: (2021)

Label-Free Proteomic Analysis of Molecular Effects of 2-Methoxy-1,4-naphthoquinone on Penicillium italicum
por: Guo, Meixia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_63mbjtt7ccejkqsn84p7r897v3