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UbiHub: a data hub for the explorers of ubiquitination pathways

MOTIVATION: Protein ubiquitination plays a central role in important cellular machineries such as protein degradation or chromatin-mediated signaling. With the recent discovery of the first potent ubiquitin-specific protease inhibitors, and the maturation of proteolysis targeting chimeras as promisi...

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Autores principales: Liu, Lihua, Damerell, David R, Koukouflis, Leonidas, Tong, Yufeng, Marsden, Brian D, Schapira, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691330/
https://www.ncbi.nlm.nih.gov/pubmed/30601939
http://dx.doi.org/10.1093/bioinformatics/bty1067
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author Liu, Lihua
Damerell, David R
Koukouflis, Leonidas
Tong, Yufeng
Marsden, Brian D
Schapira, Matthieu
author_facet Liu, Lihua
Damerell, David R
Koukouflis, Leonidas
Tong, Yufeng
Marsden, Brian D
Schapira, Matthieu
author_sort Liu, Lihua
collection PubMed
description MOTIVATION: Protein ubiquitination plays a central role in important cellular machineries such as protein degradation or chromatin-mediated signaling. With the recent discovery of the first potent ubiquitin-specific protease inhibitors, and the maturation of proteolysis targeting chimeras as promising chemical tools to exploit the ubiquitin-proteasome system, protein target classes associated with ubiquitination pathways are becoming the focus of intense drug-discovery efforts. RESULTS: We have developed UbiHub, an online resource that can be used to visualize a diverse array of biological, structural and chemical data on phylogenetic trees of human protein families involved in ubiquitination signaling, including E3 ligases and deubiquitinases. This interface can inform target prioritization and drug design, and serves as a navigation tool for medicinal chemists, structural and cell biologists exploring ubiquitination pathways. AVAILABILITY AND IMPLEMENTATION: https://ubihub.thesgc.org.
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spelling pubmed-66913302019-08-16 UbiHub: a data hub for the explorers of ubiquitination pathways Liu, Lihua Damerell, David R Koukouflis, Leonidas Tong, Yufeng Marsden, Brian D Schapira, Matthieu Bioinformatics Applications Notes MOTIVATION: Protein ubiquitination plays a central role in important cellular machineries such as protein degradation or chromatin-mediated signaling. With the recent discovery of the first potent ubiquitin-specific protease inhibitors, and the maturation of proteolysis targeting chimeras as promising chemical tools to exploit the ubiquitin-proteasome system, protein target classes associated with ubiquitination pathways are becoming the focus of intense drug-discovery efforts. RESULTS: We have developed UbiHub, an online resource that can be used to visualize a diverse array of biological, structural and chemical data on phylogenetic trees of human protein families involved in ubiquitination signaling, including E3 ligases and deubiquitinases. This interface can inform target prioritization and drug design, and serves as a navigation tool for medicinal chemists, structural and cell biologists exploring ubiquitination pathways. AVAILABILITY AND IMPLEMENTATION: https://ubihub.thesgc.org. Oxford University Press 2019-08-15 2019-01-02 /pmc/articles/PMC6691330/ /pubmed/30601939 http://dx.doi.org/10.1093/bioinformatics/bty1067 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Notes
Liu, Lihua
Damerell, David R
Koukouflis, Leonidas
Tong, Yufeng
Marsden, Brian D
Schapira, Matthieu
UbiHub: a data hub for the explorers of ubiquitination pathways
title UbiHub: a data hub for the explorers of ubiquitination pathways
title_full UbiHub: a data hub for the explorers of ubiquitination pathways
title_fullStr UbiHub: a data hub for the explorers of ubiquitination pathways
title_full_unstemmed UbiHub: a data hub for the explorers of ubiquitination pathways
title_short UbiHub: a data hub for the explorers of ubiquitination pathways
title_sort ubihub: a data hub for the explorers of ubiquitination pathways
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691330/
https://www.ncbi.nlm.nih.gov/pubmed/30601939
http://dx.doi.org/10.1093/bioinformatics/bty1067
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