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Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing

MOTIVATION: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery. Nevertheless, key limitations of the current drug connectivity-mapping paradigm have been long overlooked, including the lack of effecti...

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Detalles Bibliográficos
Autores principales: Chan, Jinyan, Wang, Xuan, Turner, Jacob A, Baldwin, Nicole E, Gu, Jinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691331/
https://www.ncbi.nlm.nih.gov/pubmed/30624606
http://dx.doi.org/10.1093/bioinformatics/btz006