Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis

Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) deposition produced by activated fibroblasts. Recent work demonstrated that excessive ECM-forming mechanical cues play an e...

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Detalles Bibliográficos
Autores principales: Li, Siyi, Li, Chao, Zhang, Yiting, He, Xiu, Chen, Xi, Zeng, Xinning, Liu, Fangwei, Chen, Ying, Chen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691376/
https://www.ncbi.nlm.nih.gov/pubmed/31410197
http://dx.doi.org/10.7150/thno.35665

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