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Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b

[Image: see text] Coproheme decarboxylase (ChdC) catalyzes the last step in the heme biosynthesis pathway of monoderm bacteria with coproheme acting both as redox cofactor and substrate. Hydrogen peroxide mediates the stepwise decarboxylation of propionates 2 and 4 of coproheme. Here we present the...

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Detalles Bibliográficos
Autores principales:	Milazzo, Lisa, Gabler, Thomas, Pühringer, Dominic, Jandova, Zuzana, Maresch, Daniel, Michlits, Hanna, Pfanzagl, Vera, Djinović-Carugo, Kristina, Oostenbrink, Chris, Furtmüller, Paul G., Obinger, Christian, Smulevich, Giulietta, Hofbauer, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691569/ https://www.ncbi.nlm.nih.gov/pubmed/31423350 http://dx.doi.org/10.1021/acscatal.9b00963

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