Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome

BACKGROUND: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. CASE REPORT: We report a patient with PHM non-responsive t...

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Autores principales: Riboldi, Giulietta M., Frucht, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691605/
https://www.ncbi.nlm.nih.gov/pubmed/31413889
http://dx.doi.org/10.7916/d8-rnsh-c024
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author Riboldi, Giulietta M.
Frucht, Steven J.
author_facet Riboldi, Giulietta M.
Frucht, Steven J.
author_sort Riboldi, Giulietta M.
collection PubMed
description BACKGROUND: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. CASE REPORT: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. DISCUSSION: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications.
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spelling pubmed-66916052019-08-14 Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome Riboldi, Giulietta M. Frucht, Steven J. Tremor Other Hyperkinet Mov (N Y) Case Reports BACKGROUND: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. CASE REPORT: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. DISCUSSION: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications. Columbia University Libraries/Information Services 2019-06-17 /pmc/articles/PMC6691605/ /pubmed/31413889 http://dx.doi.org/10.7916/d8-rnsh-c024 Text en © 2019 Riboldi & Frucht https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original authors and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Case Reports
Riboldi, Giulietta M.
Frucht, Steven J.
Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome
title Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome
title_full Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome
title_fullStr Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome
title_full_unstemmed Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome
title_short Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance–Adams Syndrome
title_sort increasing evidence for the use of sodium oxybate in multi-drug-resistant lance–adams syndrome
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691605/
https://www.ncbi.nlm.nih.gov/pubmed/31413889
http://dx.doi.org/10.7916/d8-rnsh-c024
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