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Treatment of cancer cells with chemotherapeutic drugs results in profound changes in expression of genes encoding aldehyde-metabolizing enzymes

Using RNA-seq, RT-qPCR, and bioinformatics we have studied the influence of a wide spectrum of chemotherapeutic drugs on transcription of AKR1B10, AKR1C1, ALDH1A1, and ALDH1A3 genes, which encode the major aldehyde-metabolizing enzymes. The strongest alterations were detected in case of AKR1B10 mRNA...

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Detalles Bibliográficos
Autores principales:	Zinovieva, Olga L., Grineva, Evgeniya N., Krasnov, George S., Karpov, Dmitry S., Zheltukhin, Andrei O., Snezhkina, Anastasiya V., Kudryavtseva, Anna V., Mashkova, Tamara D., Lisitsyn, Nikolai A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691692/ https://www.ncbi.nlm.nih.gov/pubmed/31413744 http://dx.doi.org/10.7150/jca.32608

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