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Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer

Objective: Whether age affects lymph node metastasis (LNM) in patients with gastric cancer (GC) is currently inconclusive. This study investigates the effect of age on LNM in patients with GC. Methods: From January 1988 to December 2013, 22,808 GC patients underwent gastrectomy at the Surveillance,...

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Autores principales: Wang, Zu-Kai, Lin, Jian-Xian, Li, Ping, Xie, Jian-Wei, Wang, Jia-Bin, Lu, Jun, Chen, Qi-Yue, Cao, Long-Long, Lin, Mi, Tu, Ru-Hong, Huang, Chang-Ming, Zheng, Chao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691700/
https://www.ncbi.nlm.nih.gov/pubmed/31413759
http://dx.doi.org/10.7150/jca.30260
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author Wang, Zu-Kai
Lin, Jian-Xian
Li, Ping
Xie, Jian-Wei
Wang, Jia-Bin
Lu, Jun
Chen, Qi-Yue
Cao, Long-Long
Lin, Mi
Tu, Ru-Hong
Huang, Chang-Ming
Zheng, Chao-Hui
author_facet Wang, Zu-Kai
Lin, Jian-Xian
Li, Ping
Xie, Jian-Wei
Wang, Jia-Bin
Lu, Jun
Chen, Qi-Yue
Cao, Long-Long
Lin, Mi
Tu, Ru-Hong
Huang, Chang-Ming
Zheng, Chao-Hui
author_sort Wang, Zu-Kai
collection PubMed
description Objective: Whether age affects lymph node metastasis (LNM) in patients with gastric cancer (GC) is currently inconclusive. This study investigates the effect of age on LNM in patients with GC. Methods: From January 1988 to December 2013, 22,808 GC patients underwent gastrectomy at the Surveillance, Epidemiology, and End Results database were included. The relationship between age and LNM was analyzed. Results: The median number of examined lymph nodes (ELNs) was 12 (interquartile range [IQR], 7-20) among the 22,808 patients with GC, and the median numbers of ELNs were 10 (IQR, 5-18), 12 (IQR, 6-19), 13 (IQR, 7-21) and 13 (IQR, 7-21) in patients with T1 to T4 disease, respectively. A total of 13,780 (60.4%) patients presented with LNM. The LNM rates were 69.6%, 66.1%, 64.7%, 61.8%, 57.8% and 55.6% for patients in the 20-39, 40-49, 50-59, 60-69, 70-79 and ≥ 80 age groups, respectively (P < 0.001). The LNM rates and the number of positive lymph nodes were correlated with age among patients whose diseases were of the same T stage (all P < 0.01). Multivariate analysis showed that age was an independent predictor for LNM in patients with early gastric cancer (EGC) (P < 0.05), and linear regression analysis showed that the LNM rate was higher in young patients with EGC (P < 0.05). Conclusions: Age is an independent predictor for LNM in EGC. Moreover, LNM is more common in young patients with EGC than in other age groups, which indicates that limited lymph node dissection may not be appropriate for young patients with EGC.
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spelling pubmed-66917002019-08-14 Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer Wang, Zu-Kai Lin, Jian-Xian Li, Ping Xie, Jian-Wei Wang, Jia-Bin Lu, Jun Chen, Qi-Yue Cao, Long-Long Lin, Mi Tu, Ru-Hong Huang, Chang-Ming Zheng, Chao-Hui J Cancer Research Paper Objective: Whether age affects lymph node metastasis (LNM) in patients with gastric cancer (GC) is currently inconclusive. This study investigates the effect of age on LNM in patients with GC. Methods: From January 1988 to December 2013, 22,808 GC patients underwent gastrectomy at the Surveillance, Epidemiology, and End Results database were included. The relationship between age and LNM was analyzed. Results: The median number of examined lymph nodes (ELNs) was 12 (interquartile range [IQR], 7-20) among the 22,808 patients with GC, and the median numbers of ELNs were 10 (IQR, 5-18), 12 (IQR, 6-19), 13 (IQR, 7-21) and 13 (IQR, 7-21) in patients with T1 to T4 disease, respectively. A total of 13,780 (60.4%) patients presented with LNM. The LNM rates were 69.6%, 66.1%, 64.7%, 61.8%, 57.8% and 55.6% for patients in the 20-39, 40-49, 50-59, 60-69, 70-79 and ≥ 80 age groups, respectively (P < 0.001). The LNM rates and the number of positive lymph nodes were correlated with age among patients whose diseases were of the same T stage (all P < 0.01). Multivariate analysis showed that age was an independent predictor for LNM in patients with early gastric cancer (EGC) (P < 0.05), and linear regression analysis showed that the LNM rate was higher in young patients with EGC (P < 0.05). Conclusions: Age is an independent predictor for LNM in EGC. Moreover, LNM is more common in young patients with EGC than in other age groups, which indicates that limited lymph node dissection may not be appropriate for young patients with EGC. Ivyspring International Publisher 2019-07-23 /pmc/articles/PMC6691700/ /pubmed/31413759 http://dx.doi.org/10.7150/jca.30260 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Zu-Kai
Lin, Jian-Xian
Li, Ping
Xie, Jian-Wei
Wang, Jia-Bin
Lu, Jun
Chen, Qi-Yue
Cao, Long-Long
Lin, Mi
Tu, Ru-Hong
Huang, Chang-Ming
Zheng, Chao-Hui
Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer
title Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer
title_full Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer
title_fullStr Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer
title_full_unstemmed Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer
title_short Higher Risk of Lymph Node Metastasis in Young Patients with Early Gastric Cancer
title_sort higher risk of lymph node metastasis in young patients with early gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691700/
https://www.ncbi.nlm.nih.gov/pubmed/31413759
http://dx.doi.org/10.7150/jca.30260
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