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Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate

The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To re...

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Detalles Bibliográficos
Autores principales: Lin, Wen, Ma, Xiaoxing, Zhou, Chaopei, Yang, Hong, Yang, Yang, Xie, Xiangyang, Yang, Chunrong, Han, Cuiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691763/
https://www.ncbi.nlm.nih.gov/pubmed/31293182
http://dx.doi.org/10.1080/10717544.2019.1639845
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author Lin, Wen
Ma, Xiaoxing
Zhou, Chaopei
Yang, Hong
Yang, Yang
Xie, Xiangyang
Yang, Chunrong
Han, Cuiyan
author_facet Lin, Wen
Ma, Xiaoxing
Zhou, Chaopei
Yang, Hong
Yang, Yang
Xie, Xiangyang
Yang, Chunrong
Han, Cuiyan
author_sort Lin, Wen
collection PubMed
description The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system.
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spelling pubmed-66917632019-08-23 Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate Lin, Wen Ma, Xiaoxing Zhou, Chaopei Yang, Hong Yang, Yang Xie, Xiangyang Yang, Chunrong Han, Cuiyan Drug Deliv Research Article The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system. Taylor & Francis 2019-07-11 /pmc/articles/PMC6691763/ /pubmed/31293182 http://dx.doi.org/10.1080/10717544.2019.1639845 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Wen
Ma, Xiaoxing
Zhou, Chaopei
Yang, Hong
Yang, Yang
Xie, Xiangyang
Yang, Chunrong
Han, Cuiyan
Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
title Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
title_full Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
title_fullStr Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
title_full_unstemmed Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
title_short Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
title_sort development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691763/
https://www.ncbi.nlm.nih.gov/pubmed/31293182
http://dx.doi.org/10.1080/10717544.2019.1639845
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