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Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691763/ https://www.ncbi.nlm.nih.gov/pubmed/31293182 http://dx.doi.org/10.1080/10717544.2019.1639845 |
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author | Lin, Wen Ma, Xiaoxing Zhou, Chaopei Yang, Hong Yang, Yang Xie, Xiangyang Yang, Chunrong Han, Cuiyan |
author_facet | Lin, Wen Ma, Xiaoxing Zhou, Chaopei Yang, Hong Yang, Yang Xie, Xiangyang Yang, Chunrong Han, Cuiyan |
author_sort | Lin, Wen |
collection | PubMed |
description | The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system. |
format | Online Article Text |
id | pubmed-6691763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-66917632019-08-23 Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate Lin, Wen Ma, Xiaoxing Zhou, Chaopei Yang, Hong Yang, Yang Xie, Xiangyang Yang, Chunrong Han, Cuiyan Drug Deliv Research Article The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system. Taylor & Francis 2019-07-11 /pmc/articles/PMC6691763/ /pubmed/31293182 http://dx.doi.org/10.1080/10717544.2019.1639845 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lin, Wen Ma, Xiaoxing Zhou, Chaopei Yang, Hong Yang, Yang Xie, Xiangyang Yang, Chunrong Han, Cuiyan Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
title | Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
title_full | Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
title_fullStr | Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
title_full_unstemmed | Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
title_short | Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
title_sort | development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691763/ https://www.ncbi.nlm.nih.gov/pubmed/31293182 http://dx.doi.org/10.1080/10717544.2019.1639845 |
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