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D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke

Ischemic stroke is a condition increasingly recognized in dogs; however, the number of publications on dogs with ischemic stroke is still limited and hemostatic parameters are infrequently reported. D-dimer levels have been shown to be elevated in people with acute ischemic stroke compared to a heal...

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Autores principales: Koch, Bodil Cathrine, Motta, Luca, Wiinberg, Bo, Westrup, Ulrik, Kristensen, Annemarie Thuri, Skerritt, Geoff, Berendt, Mette, Gredal, Hanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691767/
https://www.ncbi.nlm.nih.gov/pubmed/31448295
http://dx.doi.org/10.3389/fvets.2019.00255
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author Koch, Bodil Cathrine
Motta, Luca
Wiinberg, Bo
Westrup, Ulrik
Kristensen, Annemarie Thuri
Skerritt, Geoff
Berendt, Mette
Gredal, Hanne
author_facet Koch, Bodil Cathrine
Motta, Luca
Wiinberg, Bo
Westrup, Ulrik
Kristensen, Annemarie Thuri
Skerritt, Geoff
Berendt, Mette
Gredal, Hanne
author_sort Koch, Bodil Cathrine
collection PubMed
description Ischemic stroke is a condition increasingly recognized in dogs; however, the number of publications on dogs with ischemic stroke is still limited and hemostatic parameters are infrequently reported. D-dimer levels have been shown to be elevated in people with acute ischemic stroke compared to a healthy control population and it has been proposed that a normal D-dimer can be used to exclude thromboembolism in dogs. In this case series, we report hemostatic parameters, including D-dimer and thromboelastography (TEG) along with clinical and imaging findings for five dogs diagnosed with ischemic stroke. All dogs had a normal D-dimer concentration on presentation. A hypercoagulable state was identified in two dogs based on the results of the TEG, and was suspected in the remaining three cases based on a shortened TEG clot reaction time. Based on the findings in the present cases, a D-dimer within the normal reference range does not seem an appropriate negative predictor for canine ischemic stroke. The demonstration of a possible hypercoagulable state, as identified by the TEG, is an interesting finding which should be explored further to help reveal predisposing hypercoagulable conditions in dogs with ischemic stroke.
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spelling pubmed-66917672019-08-23 D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke Koch, Bodil Cathrine Motta, Luca Wiinberg, Bo Westrup, Ulrik Kristensen, Annemarie Thuri Skerritt, Geoff Berendt, Mette Gredal, Hanne Front Vet Sci Veterinary Science Ischemic stroke is a condition increasingly recognized in dogs; however, the number of publications on dogs with ischemic stroke is still limited and hemostatic parameters are infrequently reported. D-dimer levels have been shown to be elevated in people with acute ischemic stroke compared to a healthy control population and it has been proposed that a normal D-dimer can be used to exclude thromboembolism in dogs. In this case series, we report hemostatic parameters, including D-dimer and thromboelastography (TEG) along with clinical and imaging findings for five dogs diagnosed with ischemic stroke. All dogs had a normal D-dimer concentration on presentation. A hypercoagulable state was identified in two dogs based on the results of the TEG, and was suspected in the remaining three cases based on a shortened TEG clot reaction time. Based on the findings in the present cases, a D-dimer within the normal reference range does not seem an appropriate negative predictor for canine ischemic stroke. The demonstration of a possible hypercoagulable state, as identified by the TEG, is an interesting finding which should be explored further to help reveal predisposing hypercoagulable conditions in dogs with ischemic stroke. Frontiers Media S.A. 2019-08-06 /pmc/articles/PMC6691767/ /pubmed/31448295 http://dx.doi.org/10.3389/fvets.2019.00255 Text en Copyright © 2019 Koch, Motta, Wiinberg, Westrup, Kristensen, Skerritt, Berendt and Gredal. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Koch, Bodil Cathrine
Motta, Luca
Wiinberg, Bo
Westrup, Ulrik
Kristensen, Annemarie Thuri
Skerritt, Geoff
Berendt, Mette
Gredal, Hanne
D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
title D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
title_full D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
title_fullStr D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
title_full_unstemmed D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
title_short D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
title_sort d-dimer concentrations and thromboelastography in five dogs with ischemic stroke
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691767/
https://www.ncbi.nlm.nih.gov/pubmed/31448295
http://dx.doi.org/10.3389/fvets.2019.00255
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