Cargando…
Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients
BACKGROUND: Psoriatic arthritis is a chronic inflammatory arthropathy that affects 14%-30% of patients with skin and/or nail psoriasis, leading to severe physical limitations and disability. It has been included in the group of spondyloarthropathy with which it shares clinical, radiologic, and sero-...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691775/ https://www.ncbi.nlm.nih.gov/pubmed/29542417 http://dx.doi.org/10.2174/1574887113666180314105511 |
_version_ | 1783443447427891200 |
---|---|
author | Peluso, Rosario Caso, Francesco Tasso, Marco Ambrosino, Pasquale Di Minno, Matteo Nicola Dario Lupoli, Roberta Criscuolo, Livio Caso, Paolo Ursini, Francesco Del Puente, Antonio Scarpa, Raffaele Costa, Luisa |
author_facet | Peluso, Rosario Caso, Francesco Tasso, Marco Ambrosino, Pasquale Di Minno, Matteo Nicola Dario Lupoli, Roberta Criscuolo, Livio Caso, Paolo Ursini, Francesco Del Puente, Antonio Scarpa, Raffaele Costa, Luisa |
author_sort | Peluso, Rosario |
collection | PubMed |
description | BACKGROUND: Psoriatic arthritis is a chronic inflammatory arthropathy that affects 14%-30% of patients with skin and/or nail psoriasis, leading to severe physical limitations and disability. It has been included in the group of spondyloarthropathy with which it shares clinical, radiologic, and sero-logic features in addition to familial and genetic relationship. Beyond skin and joint involvement, psoriat-ic arthritis is characterized by a high prevalence of extra-articular manifestation and comorbidities, such as autoimmune, infectious and neoplastic diseases. In particular, an increased risk of cardiovascular comorbidity has been observed in psoriatic arthritis patients. METHODS: A systematic search was performed in the electronic databases (PubMed, Web of Science, Scopus, EMBASE) up until January 2017. Studies were included if they contained data on CV disease and/or risk factors in PsA and each article was then reviewed for quality and clinical relevance. After completing the literature search all screened literature was summarized and discussed in our study group (CaRDDs study group). All literature and comments were included in the systematic review. RESULTS: The initial search produced 278 abstracts, which were narrowed to 83 potentially relevant arti-cles by preliminary review of the titles and by excluding review articles and case report (n = 195). Thirty articles were deemed ineligible after examining the abstracts. Full texts of the remaining 53 articles were retrieved. The majority of articles excluded were due to only providing data on patients with psoriasis or due to being not relevant to the CV risk in PsA. In the end, 32 articles were deemed eligible for this re-view. CONCLUSION: Psoriatic arthritis appeared significantly associated with subclinical atherosclerosis and en-dothelial dysfunction and, in turn, with an increased cardiovascular risk. Thus, patients with psoriatic ar-thritis may benefit from a periodic assessment of surrogate markers of cardiovascular risk. This could help to establish more specific cardiovascular prevention strategies for these patients |
format | Online Article Text |
id | pubmed-6691775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-66917752019-09-05 Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients Peluso, Rosario Caso, Francesco Tasso, Marco Ambrosino, Pasquale Di Minno, Matteo Nicola Dario Lupoli, Roberta Criscuolo, Livio Caso, Paolo Ursini, Francesco Del Puente, Antonio Scarpa, Raffaele Costa, Luisa Rev Recent Clin Trials Article BACKGROUND: Psoriatic arthritis is a chronic inflammatory arthropathy that affects 14%-30% of patients with skin and/or nail psoriasis, leading to severe physical limitations and disability. It has been included in the group of spondyloarthropathy with which it shares clinical, radiologic, and sero-logic features in addition to familial and genetic relationship. Beyond skin and joint involvement, psoriat-ic arthritis is characterized by a high prevalence of extra-articular manifestation and comorbidities, such as autoimmune, infectious and neoplastic diseases. In particular, an increased risk of cardiovascular comorbidity has been observed in psoriatic arthritis patients. METHODS: A systematic search was performed in the electronic databases (PubMed, Web of Science, Scopus, EMBASE) up until January 2017. Studies were included if they contained data on CV disease and/or risk factors in PsA and each article was then reviewed for quality and clinical relevance. After completing the literature search all screened literature was summarized and discussed in our study group (CaRDDs study group). All literature and comments were included in the systematic review. RESULTS: The initial search produced 278 abstracts, which were narrowed to 83 potentially relevant arti-cles by preliminary review of the titles and by excluding review articles and case report (n = 195). Thirty articles were deemed ineligible after examining the abstracts. Full texts of the remaining 53 articles were retrieved. The majority of articles excluded were due to only providing data on patients with psoriasis or due to being not relevant to the CV risk in PsA. In the end, 32 articles were deemed eligible for this re-view. CONCLUSION: Psoriatic arthritis appeared significantly associated with subclinical atherosclerosis and en-dothelial dysfunction and, in turn, with an increased cardiovascular risk. Thus, patients with psoriatic ar-thritis may benefit from a periodic assessment of surrogate markers of cardiovascular risk. This could help to establish more specific cardiovascular prevention strategies for these patients Bentham Science Publishers 2018-09 2018-09 /pmc/articles/PMC6691775/ /pubmed/29542417 http://dx.doi.org/10.2174/1574887113666180314105511 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Peluso, Rosario Caso, Francesco Tasso, Marco Ambrosino, Pasquale Di Minno, Matteo Nicola Dario Lupoli, Roberta Criscuolo, Livio Caso, Paolo Ursini, Francesco Del Puente, Antonio Scarpa, Raffaele Costa, Luisa Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients |
title | Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients |
title_full | Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients |
title_fullStr | Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients |
title_full_unstemmed | Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients |
title_short | Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients |
title_sort | cardiovascular risk markers and major adverse cardiovascular events in psoriatic arthritis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691775/ https://www.ncbi.nlm.nih.gov/pubmed/29542417 http://dx.doi.org/10.2174/1574887113666180314105511 |
work_keys_str_mv | AT pelusorosario cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT casofrancesco cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT tassomarco cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT ambrosinopasquale cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT diminnomatteonicoladario cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT lupoliroberta cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT criscuololivio cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT casopaolo cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT ursinifrancesco cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT delpuenteantonio cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT scarparaffaele cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT costaluisa cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients AT cardiovascularriskmarkersandmajoradversecardiovasculareventsinpsoriaticarthritispatients |