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Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment
BACKGROUND: Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia. OBJECTIVE: The first systematic study to determine whether six to 12 days’ intravenous ceftriaxone treat-ment is associat...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691780/ https://www.ncbi.nlm.nih.gov/pubmed/29769008 http://dx.doi.org/10.2174/1574887113666180517072744 |
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author | Puri, Basant K. Derham, Anne Monro, Jean A. |
author_facet | Puri, Basant K. Derham, Anne Monro, Jean A. |
author_sort | Puri, Basant K. |
collection | PubMed |
description | BACKGROUND: Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia. OBJECTIVE: The first systematic study to determine whether six to 12 days’ intravenous ceftriaxone treat-ment is associated with a reduction in the neutrophil count and the extent to which biochemical and/or haematological parameters routinely measured at baseline predict such a fall. METHOD: Baseline and follow-up haematological and biochemical blood indices were measured in 86 pa-tients (mean age 39.4 years; 55 female) receiving 2 g intravenous ceftriaxone daily. RESULTS: At follow-up, the mean (standard error) neutrophil count had fallen from 3.93 × 109 (0.16 × 109) L-1 to 3.15 × 109 (0.15 × 109) L-1 (p < 0.000001). This reduction was predictable according to the following multifactor linear regression model: (baseline neutrophil count (× 109 L-1)) – (follow-up neu-trophil count (× 109 L-1)) = 76 + 159.2(baseline haematocrit) – 14.5(baseline red blood cell count (× 1012 L-1)) – 0.724(baseline mean corpuscular volume (fL)) + 0.474(baseline neutrophil count (× 109 L-1)) + 0.0448(baseline total iron binding capacity (μM)) + 7.15(baseline calcium ion concentration (mM)) – 13.2(baseline corrected calcium ion concentration (mM)) + 0.0166(baseline alkaline phosphatase (IU L-1)). The residuals were normally distributed and model testing by random partition of the original data into two parts, with training of the model using the first part and model testing with the second part, gave highly satisfactory results. CONCLUSION: Intravenous ceftriaxone treatment is associated with a fall in neutrophils, which can be pre-dicted by routine baseline blood indices |
format | Online Article Text |
id | pubmed-6691780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-66917802019-09-05 Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment Puri, Basant K. Derham, Anne Monro, Jean A. Rev Recent Clin Trials Article BACKGROUND: Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia. OBJECTIVE: The first systematic study to determine whether six to 12 days’ intravenous ceftriaxone treat-ment is associated with a reduction in the neutrophil count and the extent to which biochemical and/or haematological parameters routinely measured at baseline predict such a fall. METHOD: Baseline and follow-up haematological and biochemical blood indices were measured in 86 pa-tients (mean age 39.4 years; 55 female) receiving 2 g intravenous ceftriaxone daily. RESULTS: At follow-up, the mean (standard error) neutrophil count had fallen from 3.93 × 109 (0.16 × 109) L-1 to 3.15 × 109 (0.15 × 109) L-1 (p < 0.000001). This reduction was predictable according to the following multifactor linear regression model: (baseline neutrophil count (× 109 L-1)) – (follow-up neu-trophil count (× 109 L-1)) = 76 + 159.2(baseline haematocrit) – 14.5(baseline red blood cell count (× 1012 L-1)) – 0.724(baseline mean corpuscular volume (fL)) + 0.474(baseline neutrophil count (× 109 L-1)) + 0.0448(baseline total iron binding capacity (μM)) + 7.15(baseline calcium ion concentration (mM)) – 13.2(baseline corrected calcium ion concentration (mM)) + 0.0166(baseline alkaline phosphatase (IU L-1)). The residuals were normally distributed and model testing by random partition of the original data into two parts, with training of the model using the first part and model testing with the second part, gave highly satisfactory results. CONCLUSION: Intravenous ceftriaxone treatment is associated with a fall in neutrophils, which can be pre-dicted by routine baseline blood indices Bentham Science Publishers 2018-12 2018-12 /pmc/articles/PMC6691780/ /pubmed/29769008 http://dx.doi.org/10.2174/1574887113666180517072744 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Puri, Basant K. Derham, Anne Monro, Jean A. Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment |
title | Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment |
title_full | Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment |
title_fullStr | Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment |
title_full_unstemmed | Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment |
title_short | Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment |
title_sort | biochemical and haematological predictors of reduced neutrophil granulocyte count associated with intravenous ceftriaxone treatment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691780/ https://www.ncbi.nlm.nih.gov/pubmed/29769008 http://dx.doi.org/10.2174/1574887113666180517072744 |
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