1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and assess a protocol to derive ligand epitope mapping from WaterLOGSY data and...

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Detalles Bibliográficos
Autores principales: Raingeval, Claire, Cala, Olivier, Brion, Béatrice, Le Borgne, Marc, Hubbard, Roderick Eliot, Krimm, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691826/
https://www.ncbi.nlm.nih.gov/pubmed/31286785
http://dx.doi.org/10.1080/14756366.2019.1636235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691826/
https://www.ncbi.nlm.nih.gov/pubmed/31286785
http://dx.doi.org/10.1080/14756366.2019.1636235

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