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Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study

OBJECTIVE: Colorectal cancer is one of the most frequent types of malignant neoplasms. Age is a risk factor for this disease, with 75% of cases diagnosed in patients older than 65 years. Complications such as obstruction, hemorrhage, and perforation are present in more than one-third of cases and re...

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Autores principales: Menegozzo, Carlos Augusto Metidieri, Teixeira-Júnior, Frederico, do Couto-Netto, Sérgio Dias, Martins-Júnior, Octacílio, de Oliveira Bernini, Celso, Utiyama, Edivaldo Massazo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691836/
https://www.ncbi.nlm.nih.gov/pubmed/31433041
http://dx.doi.org/10.6061/clinics/2019/e1074
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author Menegozzo, Carlos Augusto Metidieri
Teixeira-Júnior, Frederico
do Couto-Netto, Sérgio Dias
Martins-Júnior, Octacílio
de Oliveira Bernini, Celso
Utiyama, Edivaldo Massazo
author_facet Menegozzo, Carlos Augusto Metidieri
Teixeira-Júnior, Frederico
do Couto-Netto, Sérgio Dias
Martins-Júnior, Octacílio
de Oliveira Bernini, Celso
Utiyama, Edivaldo Massazo
author_sort Menegozzo, Carlos Augusto Metidieri
collection PubMed
description OBJECTIVE: Colorectal cancer is one of the most frequent types of malignant neoplasms. Age is a risk factor for this disease, with 75% of cases diagnosed in patients older than 65 years. Complications such as obstruction, hemorrhage, and perforation are present in more than one-third of cases and require emergency treatment. We aim to analyze the profile of elderly patients undergoing surgery for complicated colorectal cancer, and to evaluate factors related to worse short-term prognosis. METHODS: A retrospective analysis of patients who underwent emergency surgical treatment for complicated colorectal cancer was performed. Demographics, clinical, radiological and histological data were collected. RESULTS: Sixty-seven patients were analyzed. The median age was 72 years, and almost half (46%) of the patients were female. Obstruction was the most prevalent complication at initial presentation (72%). The most common sites of neoplasia were the left and sigmoid colon in 22 patients (32.8%), and the right colon in 17 patients (25.4%). Resection was performed in 88% of cases, followed by primary anastomosis in almost half. The most frequent clinical stages were II (48%) and III (22%). Forty-three patients (65.7%) had some form of postoperative complication. Clavien-Dindo grades 1, 2, and 4, were the most frequent. Complete oncologic resection was observed in 80% of the cases. The thirty-day mortality rate was 10.4%. Advanced age was associated with worse morbidity and mortality. CONCLUSION: Elderly patients with complicated colorectal cancer undergoing emergency surgery have high morbidity and mortality rates. Advanced age is significantly associated with worse outcomes.
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spelling pubmed-66918362019-09-16 Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study Menegozzo, Carlos Augusto Metidieri Teixeira-Júnior, Frederico do Couto-Netto, Sérgio Dias Martins-Júnior, Octacílio de Oliveira Bernini, Celso Utiyama, Edivaldo Massazo Clinics (Sao Paulo) Original Article OBJECTIVE: Colorectal cancer is one of the most frequent types of malignant neoplasms. Age is a risk factor for this disease, with 75% of cases diagnosed in patients older than 65 years. Complications such as obstruction, hemorrhage, and perforation are present in more than one-third of cases and require emergency treatment. We aim to analyze the profile of elderly patients undergoing surgery for complicated colorectal cancer, and to evaluate factors related to worse short-term prognosis. METHODS: A retrospective analysis of patients who underwent emergency surgical treatment for complicated colorectal cancer was performed. Demographics, clinical, radiological and histological data were collected. RESULTS: Sixty-seven patients were analyzed. The median age was 72 years, and almost half (46%) of the patients were female. Obstruction was the most prevalent complication at initial presentation (72%). The most common sites of neoplasia were the left and sigmoid colon in 22 patients (32.8%), and the right colon in 17 patients (25.4%). Resection was performed in 88% of cases, followed by primary anastomosis in almost half. The most frequent clinical stages were II (48%) and III (22%). Forty-three patients (65.7%) had some form of postoperative complication. Clavien-Dindo grades 1, 2, and 4, were the most frequent. Complete oncologic resection was observed in 80% of the cases. The thirty-day mortality rate was 10.4%. Advanced age was associated with worse morbidity and mortality. CONCLUSION: Elderly patients with complicated colorectal cancer undergoing emergency surgery have high morbidity and mortality rates. Advanced age is significantly associated with worse outcomes. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2019-08-13 2019 /pmc/articles/PMC6691836/ /pubmed/31433041 http://dx.doi.org/10.6061/clinics/2019/e1074 Text en Copyright © 2019 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
spellingShingle Original Article
Menegozzo, Carlos Augusto Metidieri
Teixeira-Júnior, Frederico
do Couto-Netto, Sérgio Dias
Martins-Júnior, Octacílio
de Oliveira Bernini, Celso
Utiyama, Edivaldo Massazo
Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study
title Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study
title_full Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study
title_fullStr Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study
title_full_unstemmed Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study
title_short Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study
title_sort outcomes of elderly patients undergoing emergency surgery for complicated colorectal cancer: a retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691836/
https://www.ncbi.nlm.nih.gov/pubmed/31433041
http://dx.doi.org/10.6061/clinics/2019/e1074
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