Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

OBJECTIVES: Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive muscularis macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 recept...

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Detalles Bibliográficos
Autores principales: Stakenborg, Nathalie, Labeeuw, Evelien, Gomez-Pinilla, Pedro J, De Schepper, Sebastiaan, Aerts, Raymond, Goverse, Gera, Farro, Giovanna, Appeltans, Iris, Meroni, Elisa, Stakenborg, Michelle, Viola, Maria Francesca, Gonzalez-Dominguez, Erika, Bosmans, Goele, Alpizar, Yeranddy A, Wolthuis, Albert, D’Hoore, Andre, Van Beek, Kim, Verheijden, Simon, Verhaegen, Marleen, Derua, Rita, Waelkens, Etienne, Moretti, Milena, Gotti, Cecilia, Augustijns, Patrick, Talavera, Karel, Vanden Berghe, Pieter, Matteoli, Gianluca, Boeckxstaens, Guy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Neurogastroenterology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691854/
https://www.ncbi.nlm.nih.gov/pubmed/30472681
http://dx.doi.org/10.1136/gutjnl-2018-317263

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