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Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial
OBJECTIVE: To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses. DESIGN: Twelve non-diabetic adults with overweight...
Autores principales: | Chambers, Edward S, Byrne, Claire S, Morrison, Douglas J, Murphy, Kevin G, Preston, Tom, Tedford, Catriona, Garcia-Perez, Isabel, Fountana, Sofia, Serrano-Contreras, Jose Ivan, Holmes, Elaine, Reynolds, Catherine J, Roberts, Jordie F, Boyton, Rosemary J, Altmann, Daniel M, McDonald, Julie A K, Marchesi, Julian R, Akbar, Arne N, Riddell, Natalie E, Wallis, Gareth A, Frost, Gary S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691855/ https://www.ncbi.nlm.nih.gov/pubmed/30971437 http://dx.doi.org/10.1136/gutjnl-2019-318424 |
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