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Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes

OBJECTIVE: A hallmark of amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase-1 (SOD1) are inclusions containing SOD1 in motor neurons. Here, we searched for SOD1-positive inclusions in 29 patients carrying ALS-linked mutations in six other genes. METHODS: A panel of antib...

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Detalles Bibliográficos
Autores principales:	Forsberg, Karin, Graffmo, Karin, Pakkenberg, Bente, Weber, Markus, Nielsen, Martin, Marklund, Stefan, Brännström, Thomas, Andersen, Peter Munch
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Neurodegeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691870/ https://www.ncbi.nlm.nih.gov/pubmed/30992335 http://dx.doi.org/10.1136/jnnp-2018-319386

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