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Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo

BIN1 is the most important risk locus for Late Onset Alzheimer’s Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as with brain atrophy. Furthermore, the level of neuronal-specific BIN1 isoform 1 protein is decreased in sporadic AD cases in parallel with neur...

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Detalles Bibliográficos
Autores principales:	McAvoy, Kathleen M., Rajamohamed Sait, Hameetha, Marsh, Galina, Peterson, Michael, Reynolds, Taylor L., Gagnon, Jake, Geisler, Sarah, Leach, Prescott, Roberts, Chris, Cahir-McFarland, Ellen, Ransohoff, Richard M., Crotti, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692034/ https://www.ncbi.nlm.nih.gov/pubmed/31408457 http://dx.doi.org/10.1371/journal.pone.0220125

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