Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. Previously we used ancestral reconstruction to determine how CMGC group kinase specificity evolved (Howard et al., 2014). In the present study, we reconstructed ancestral kinases to st...

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Detalles Bibliográficos
Autores principales: Sang, Dajun, Pinglay, Sudarshan, Wiewiora, Rafal P, Selvan, Myvizhi E, Lou, Hua Jane, Chodera, John D, Turk, Benjamin E, Gümüş, Zeynep H, Holt, Liam J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692128/
https://www.ncbi.nlm.nih.gov/pubmed/31407663
http://dx.doi.org/10.7554/eLife.38805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692128/
https://www.ncbi.nlm.nih.gov/pubmed/31407663
http://dx.doi.org/10.7554/eLife.38805

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