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Targeting HIBCH to reprogram valine metabolism for the treatment of colorectal cancer

Valine catabolism is known to be essential for cancer cells but the detailed mechanism remains unclear. This study is to explore the critical roles of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) in colorectal cancers (CRC) and to develop a new therapy returning valine metabolism homeostasis. High HIBC...

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Detalles Bibliográficos
Autores principales:	Shan, Yunlong, Gao, Yuan, Jin, Wei, Fan, Minmin, Wang, Ying, Gu, Yanhong, Shan, Chenxiao, Sun, Lijun, Li, Xin, Yu, Biao, Luo, Qiong, Xu, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692300/ https://www.ncbi.nlm.nih.gov/pubmed/31409769 http://dx.doi.org/10.1038/s41419-019-1832-6

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