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Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways
Rational choice theory assumes optimality in decision-making. Violations of a basic axiom of economic rationality known as “Independence of Irrelevant Alternatives” (IIA) have been demonstrated in both humans and animals and could stem from common neuronal constraints. Here we develop tests for IIA...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692327/ https://www.ncbi.nlm.nih.gov/pubmed/31409788 http://dx.doi.org/10.1038/s41467-019-11715-7 |
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author | Cohen, Dror Teichman, Guy Volovich, Meshi Zeevi, Yoav Elbaum, Lilach Madar, Asaf Louie, Kenway Levy, Dino J. Rechavi, Oded |
author_facet | Cohen, Dror Teichman, Guy Volovich, Meshi Zeevi, Yoav Elbaum, Lilach Madar, Asaf Louie, Kenway Levy, Dino J. Rechavi, Oded |
author_sort | Cohen, Dror |
collection | PubMed |
description | Rational choice theory assumes optimality in decision-making. Violations of a basic axiom of economic rationality known as “Independence of Irrelevant Alternatives” (IIA) have been demonstrated in both humans and animals and could stem from common neuronal constraints. Here we develop tests for IIA in the nematode Caenorhabditis elegans, an animal with only 302 neurons, using olfactory chemotaxis assays. We find that in most cases C. elegans make rational decisions. However, by probing multiple neuronal architectures using various choice sets, we show that violations of rationality arise when the circuit of olfactory sensory neurons is asymmetric. We further show that genetic manipulations of the asymmetry between the AWC neurons can make the worm irrational. Last, a context-dependent normalization-based model of value coding and gain control explains how particular neuronal constraints on information coding give rise to irrationality. Thus, we demonstrate that bounded rationality could arise due to basic neuronal constraints. |
format | Online Article Text |
id | pubmed-6692327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66923272019-08-15 Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways Cohen, Dror Teichman, Guy Volovich, Meshi Zeevi, Yoav Elbaum, Lilach Madar, Asaf Louie, Kenway Levy, Dino J. Rechavi, Oded Nat Commun Article Rational choice theory assumes optimality in decision-making. Violations of a basic axiom of economic rationality known as “Independence of Irrelevant Alternatives” (IIA) have been demonstrated in both humans and animals and could stem from common neuronal constraints. Here we develop tests for IIA in the nematode Caenorhabditis elegans, an animal with only 302 neurons, using olfactory chemotaxis assays. We find that in most cases C. elegans make rational decisions. However, by probing multiple neuronal architectures using various choice sets, we show that violations of rationality arise when the circuit of olfactory sensory neurons is asymmetric. We further show that genetic manipulations of the asymmetry between the AWC neurons can make the worm irrational. Last, a context-dependent normalization-based model of value coding and gain control explains how particular neuronal constraints on information coding give rise to irrationality. Thus, we demonstrate that bounded rationality could arise due to basic neuronal constraints. Nature Publishing Group UK 2019-08-13 /pmc/articles/PMC6692327/ /pubmed/31409788 http://dx.doi.org/10.1038/s41467-019-11715-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cohen, Dror Teichman, Guy Volovich, Meshi Zeevi, Yoav Elbaum, Lilach Madar, Asaf Louie, Kenway Levy, Dino J. Rechavi, Oded Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways |
title | Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways |
title_full | Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways |
title_fullStr | Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways |
title_full_unstemmed | Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways |
title_short | Bounded rationality in C. elegans is explained by circuit-specific normalization in chemosensory pathways |
title_sort | bounded rationality in c. elegans is explained by circuit-specific normalization in chemosensory pathways |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692327/ https://www.ncbi.nlm.nih.gov/pubmed/31409788 http://dx.doi.org/10.1038/s41467-019-11715-7 |
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