Cerumenogram: a new frontier in cancer diagnosis in humans

Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collec...

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Detalles Bibliográficos
Autores principales: Barbosa, João Marcos Gonçalves, Pereira, Naiara Zedes, David, Lurian Caetano, de Oliveira, Camilla Gabriela, Soares, Marina Ferraz Gontijo, Avelino, Melissa Ameloti Gomes, de Oliveira, Anselmo Elcana, Shokry, Engy, Filho, Nelson Roberto Antoniosi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692389/
https://www.ncbi.nlm.nih.gov/pubmed/31409861
http://dx.doi.org/10.1038/s41598-019-48121-4
Descripción
Sumario:Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate.

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