Cerumenogram: a new frontier in cancer diagnosis in humans

Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collec...

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Autores principales: Barbosa, João Marcos Gonçalves, Pereira, Naiara Zedes, David, Lurian Caetano, de Oliveira, Camilla Gabriela, Soares, Marina Ferraz Gontijo, Avelino, Melissa Ameloti Gomes, de Oliveira, Anselmo Elcana, Shokry, Engy, Filho, Nelson Roberto Antoniosi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692389/
https://www.ncbi.nlm.nih.gov/pubmed/31409861
http://dx.doi.org/10.1038/s41598-019-48121-4
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author Barbosa, João Marcos Gonçalves
Pereira, Naiara Zedes
David, Lurian Caetano
de Oliveira, Camilla Gabriela
Soares, Marina Ferraz Gontijo
Avelino, Melissa Ameloti Gomes
de Oliveira, Anselmo Elcana
Shokry, Engy
Filho, Nelson Roberto Antoniosi
author_facet Barbosa, João Marcos Gonçalves
Pereira, Naiara Zedes
David, Lurian Caetano
de Oliveira, Camilla Gabriela
Soares, Marina Ferraz Gontijo
Avelino, Melissa Ameloti Gomes
de Oliveira, Anselmo Elcana
Shokry, Engy
Filho, Nelson Roberto Antoniosi
author_sort Barbosa, João Marcos Gonçalves
collection PubMed
description Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate.
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spelling pubmed-66923892019-08-19 Cerumenogram: a new frontier in cancer diagnosis in humans Barbosa, João Marcos Gonçalves Pereira, Naiara Zedes David, Lurian Caetano de Oliveira, Camilla Gabriela Soares, Marina Ferraz Gontijo Avelino, Melissa Ameloti Gomes de Oliveira, Anselmo Elcana Shokry, Engy Filho, Nelson Roberto Antoniosi Sci Rep Article Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate. Nature Publishing Group UK 2019-08-13 /pmc/articles/PMC6692389/ /pubmed/31409861 http://dx.doi.org/10.1038/s41598-019-48121-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Barbosa, João Marcos Gonçalves
Pereira, Naiara Zedes
David, Lurian Caetano
de Oliveira, Camilla Gabriela
Soares, Marina Ferraz Gontijo
Avelino, Melissa Ameloti Gomes
de Oliveira, Anselmo Elcana
Shokry, Engy
Filho, Nelson Roberto Antoniosi
Cerumenogram: a new frontier in cancer diagnosis in humans
title Cerumenogram: a new frontier in cancer diagnosis in humans
title_full Cerumenogram: a new frontier in cancer diagnosis in humans
title_fullStr Cerumenogram: a new frontier in cancer diagnosis in humans
title_full_unstemmed Cerumenogram: a new frontier in cancer diagnosis in humans
title_short Cerumenogram: a new frontier in cancer diagnosis in humans
title_sort cerumenogram: a new frontier in cancer diagnosis in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692389/
https://www.ncbi.nlm.nih.gov/pubmed/31409861
http://dx.doi.org/10.1038/s41598-019-48121-4
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