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Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA

The N-methyl-D-aspartate (NMDA) receptor has been implicated in several neurodegenerative diseases, including stroke. Low-density lipoprotein receptor-related protein 1 (LRP1) plays pivotal roles in endocytosis and signaling in the cell. Immature LRP1 is processed by furin in the trans-Golgi network...

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Detalles Bibliográficos
Autores principales:	Yamada, Mariko, Hayashi, Hideki, Suzuki, Kaori, Sato, Shoko, Inoue, Daisuke, Iwatani, Yui, Ohata, Meiko, Yuan, Bo, Takagi, Norio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692408/ https://www.ncbi.nlm.nih.gov/pubmed/31409872 http://dx.doi.org/10.1038/s41598-019-48279-x

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