IL-36β Promotes CD8(+) T Cell Activation and Antitumor Immune Responses by Activating mTORC1

Cytokine-amplified functional CD8(+) T cells ensure effective eradication of tumors. Interleukin 36α (IL-36α), IL-36β, and IL-36γ share the same receptor complex, composed of the IL-36 receptor (IL-36R), and IL-1RAcP. Recently, we revealed that IL-36γ greatly promoted CD8(+) T cell activation, contr...

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Detalles Bibliográficos
Autores principales: Zhao, Xin, Chen, Xiaojuan, Shen, Xinghua, Tang, Peijun, Chen, Chen, Zhu, Qitai, Li, Muyao, Xia, Rui, Yang, Xi, Feng, Chao, Zhu, Xinguo, Zhu, Yibei, Sun, Zhongwen, Zhang, Xueguang, Lu, Binfeng, Wang, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692458/
https://www.ncbi.nlm.nih.gov/pubmed/31447838
http://dx.doi.org/10.3389/fimmu.2019.01803

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